Id-1 promotes proliferation of p53-deficient esophageal cancer cells

International Journal of Cancer. Journal International Du Cancer
Cheuk Man HuiAnnie L M Cheung

Abstract

The helix-loop-helix protein inhibitor of differentiation and DNA binding (Id-1) is known to promote cellular proliferation in several types of human cancer. Although it has been reported that Id-1 is over-expressed in esophageal squamous cell carcinoma (ESCC), its function and signaling pathways in esophageal cancer are unknown. In our study, we investigated the direct effects of Id-1 on esophageal cancer cell growth by transfecting an Id-1 expression vector into an ESCC cell line (HKESC-3), which showed serum-dependent Id-1 expression. Ectopic Id-1 expression resulted in increased serum-independent cell growth and G1-S phase transition, as well as up-regulation of mouse double minute 2 (MDM2) and down-regulation of p21Waf1/Cip1 protein expressions in the transfectant clones in a p53-independent manner. However, overexpression of Id-1 had no effect on the pRB, CDK4 and p16INK4A expressions. Stable transfection of Id-1 antisense expression vector to inhibit the expression of endogenous Id-1 in another ESCC cell line (HKESC-1) reversed the effects on MDM2 and p21Waf1/Cip1. In addition, Id-1 expression protected ESCC cells from Tumor Necrosis Factor (TNF)-alpha-induced apoptosis by up-regulating and activating Bcl-2. In conclusio...Continue Reading

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Citations

Dec 26, 2007·Breast Cancer Research and Treatment·Hwan KimGu Kong
May 18, 2012·American Journal of Physiology. Cell Physiology·Xiao PengDeming Gou
Nov 17, 2015·Expert Opinion on Therapeutic Targets·Jin LiAnnie Lm Cheung
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shan ZhouFaqing Tang
May 10, 2008·Molecular Nutrition & Food Research·Liping LiuMohsen Meydani
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Bin LiAnnie L M Cheung
Oct 3, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Hongjiang SongChunfang Song
Aug 25, 2007·The American Journal of Pathology·Huimin ZhangChin Chiang
Aug 21, 2013·Biochimica Et Biophysica Acta·Thera C Lewis, Ron Prywes
Sep 15, 2017·International Journal of Cancer. Journal International Du Cancer·Jia LiuAnnie L M Cheung
Jan 21, 2014·Nature Reviews. Cancer·Anna LasorellaAntonio Iavarone
Jun 8, 2017·Experimental and Therapeutic Medicine·Xiaopo HeShaohua Liu
Mar 7, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bin LiAnnie L M Cheung

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