Id2 Determines Intestinal Identity through Repression of the Foregut Transcription Factor Irx5

Molecular and Cellular Biology
Kentaro MoriY Yokota

Abstract

The cellular components and function of the gastrointestinal epithelium exhibit distinct characteristics depending on the region, e.g., stomach or intestine. How these region-specific epithelial characteristics are generated during development remains poorly understood. Here, we report on the involvement of the helix-loop-helix inhibitor Id2 in establishing the specific characteristics of the intestinal epithelium. Id2-/- mice developed tumors in the small intestine. Histological analysis indicated that the intestinal tumors were derived from gastric metaplasia formed in the small intestine during development. Heterotopic Id2 expression in developing gastric epithelium induced a fate change to intestinal epithelium. Gene expression analysis revealed that foregut-enriched genes encoding Irx3 and Irx5 were highly induced in the midgut of Id2-/- embryos, and transgenic mice expressing Irx5 in the midgut endoderm developed tumors recapitulating the characteristics of Id2-/- mice. Altogether, our results demonstrate that Id2 plays a crucial role in the development of regional specificity in the gastrointestinal epithelium.

References

Nov 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y JenR Benezra
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·F BeckJ B Furness
Dec 28, 1999·Molecular and Cellular Biology·M E Massari, C Murre
Oct 21, 2000·Gastroenterology·D G SilbergP G Traber
Nov 4, 2000·The EMBO Journal·S MoriY Yokota
Aug 25, 2001·Mechanisms of Development·A C HouwelingV M Christoffels
Jul 9, 2002·Current Opinion in Genetics & Development·José Luis Gómez-Skarmeta, Juan Modolell
Dec 17, 2002·Nature Immunology·Manabu SugaiAkira Shimizu
Aug 2, 2003·Nature Reviews. Cancer·Yasuhito Yuasa
Oct 20, 2004·Cancer Research·Robert G RussellAntonio Iavarone
May 6, 2005·Cytokine & Growth Factor Reviews·Kohei MiyazonoTakeshi Imamura
Nov 22, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Minke van TuylMartin Post
Jan 19, 2006·The Journal of Investigative Dermatology·Michael Girardi
Mar 16, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lorene E BattsHolger Kulessa
Mar 23, 2007·Nature Reviews. Molecular Cell Biology·Jonathan M W Slack
Aug 8, 2007·Gastroenterology·Byeong-Moo KimRamesh A Shivdasani
Dec 20, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Richard I SherwoodDouglas A Melton
Mar 6, 2009·Gastroenterology·Makoto Mark Taketo, Winfried Edelmann
Apr 24, 2009·Developmental Cell·Nan GaoKlaus H Kaestner
Apr 28, 2009·Gene Expression Patterns : GEP·Shahab M DaneshOndine Cleaver
May 30, 2009·The Journal of Comparative Neurology·Yasuhito WatanabeToru Takumi
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Aaron M Zorn, James M Wells
Jan 2, 2010·Developmental Biology·Stephanie GraingerDavid Lohnes
Jan 19, 2010·The Journal of Surgical Research·Hai-Yan YangHong-Chi Jiang
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anja RagvinThomas S Becker
Aug 3, 2010·Biochemical and Biophysical Research Communications·Takeshi NakahiroYoshifumi Yokota
Nov 12, 2010·Development·Pavel RodriguezJianwen Que
Aug 17, 2011·Diabetes, Obesity & Metabolism·H J LiA B Leiter
Aug 23, 2011·Mechanisms of Development·Richard I SherwoodDouglas A Melton
May 15, 2012·Nature Genetics·Carine BonnardBruno Reversade
Jun 9, 2012·Journal of Molecular Cell Biology·Lalini RaghoebirRobbert J Rottier
Aug 21, 2012·Current Biology : CB·Andrey N KuzmichevRonald D McKay

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Citations

Sep 25, 2018·The Journal of Pathology·Linda Holmquist MengelbierDavid Gisselsson
Apr 16, 2019·Data in Brief·Kentaro MoriYoshifumi Yokota

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Datasets Mentioned

BETA
GSE43014

Methods Mentioned

BETA
reverse-transcription PCR
PCR

Software Mentioned

TOP
GAL

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