Id2 regulates hyporesponsive invariant natural killer T cells

Immunology and Cell Biology
Martin H StradnerLouise M D'Cruz

Abstract

While the invariant natural killer T (iNKT)-cell response to primary stimulation with the glycolipid, α-galactosylceramide (αGalCer), is robust, the secondary response to this stimulus is muted resulting in a hyporesponsive state characterized by anti-inflammatory interleukin-10 (IL-10) production and high expression of programmed cell death 1 (PD1) and neuropilin 1 (NRP1). The E protein transcription factors and their negative regulators, the Id proteins, have previously been shown to regulate iNKT cell thymic development, subset differentiation and peripheral survival. Here, we provide evidence that the expression of the transcriptional regulator Id2 is downregulated upon stimulation of iNKT cells with their cognate antigen. Moreover, loss of Id2 expression by iNKT cells resulted in a hyporesponsive state, with splenic Id2-deficient iNKT cells expressing low levels of TBET, high levels of PD1 and NRP1 and production of IL-10 upon stimulation. We propose that downregulation of Id2 expression is an essential component of induction of the anti-inflammatory, hyporesponsive state in iNKT cells.

References

Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Takashi KusunokiYoshifumi Yokota
Apr 16, 2004·Immunity·Michael J TownsendLaurie H Glimcher
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aki IshikawaTakehiko Fujisawa
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam P UldrichDale I Godfrey
Sep 3, 2005·The Journal of Clinical Investigation·Barbara A Sullivan, Mitchell Kronenberg
Sep 3, 2005·The Journal of Clinical Investigation·Vrajesh V ParekhLuc Van Kaer
Dec 8, 2006·Annual Review of Immunology·Albert BendelacLuc Teyton
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niranjana A Nagarajan, Mitchell Kronenberg
May 27, 2008·Current Opinion in Immunology·Jennifer L MatsudaLaurent Gapin
Nov 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Laurel A MonticelliAnanda W Goldrath
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jing WangDirk M Zajonc
Oct 8, 2013·Current Opinion in Immunology·Kyla D OmilusikAnanda W Goldrath
Nov 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mihalis VerykokakisBarbara L Kee
Jan 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Louise M D'CruzAnanda W Goldrath
Feb 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinhong WuXiao-Ping Zhong
Apr 12, 2014·Journal of Immunological Methods·Silke SohnTonya J Webb
Apr 12, 2014·Blood·Frederick MassonGabrielle T Belz
Jun 30, 2014·Nature Immunology·Masaki MiyazakiCornelis Murre
Jul 26, 2014·The Journal of Clinical Investigation·Duygu SagGerhard Wingender
Aug 16, 2014·Immunological Reviews·Mihalis VerykokakisBarbara L Kee
Sep 25, 2014·Current Topics in Developmental Biology·Ian Belle, Yuan Zhuang
May 6, 2015·Cancer Immunology Research·Rosanna M McEwen-SmithVincenzo Cerundolo
Sep 5, 2015·Oncotarget·Gerhard WingenderMitchell Kronenberg
Sep 12, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gerhard WingenderMitchell Kronenberg

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Citations

May 4, 2016·Immunology and Cell Biology·Daniel G Pellicci, Adam P Uldrich

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