Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice

Genes and Immunity
Véronique DugasSylvie Lesage

Abstract

Immunoregulatory T cells have been identified as key modulators of peripheral tolerance and participate in preventing autoimmune diseases. CD4(-)CD8(-) (double negative, DN) T cells compose one of these immunoregulatory T-cell subsets, where the injection of DN T cells confers protection from autoimmune diabetes progression. Interestingly, genetic loci defining the function and number of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) coincide with at least some autoimmune disease susceptibility loci. Herein, we investigate the impact of major insulin-dependent diabetes (Idd) loci in defining the number of DN T cells. We demonstrate that although Idd3, Idd5 and Idd9 loci do not regulate DN T-cell number, NOD mice congenic for diabetes resistance alleles at the Idd13 locus show a partial restoration in DN T-cell number. Moreover, competitive and non-competitive bone marrow chimera experiments reveal that DN T-cell number is defined by a bone marrow-intrinsic, but DN T-cell-extrinsic, factor. This suggests that non-autonomous candidate genes define DN T-cell number in secondary lymphoid organs. Together, our results show that the regulation of DN T-cell number in NOD mice is at least partially conferred by alleles at the Idd13 l...Continue Reading

References

Aug 1, 1993·Nature Genetics·S GhoshL B Peterson
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·E E Hamilton-WilliamsR M Slattery
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
Nov 6, 2002·The Journal of Experimental Medicine·Sylvie LesageChristopher C Goodnow
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luis M EstebanAlan G Baxter
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter J NorsworthyMarina Botto
Mar 18, 2005·Annual Review of Immunology·Mark S Anderson, Jeffrey A Bluestone
Mar 23, 2005·Immunity·Silvia ZucchelliDiane Mathis
Oct 18, 2005·Current Opinion in Immunology·Lisa M Maier, Linda S Wicker
Nov 1, 2005·Journal of Autoimmunity·Linda S WickerLaurence B Peterson
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ellen M van BeekTimo K van den Berg
Aug 22, 2006·Inflammation & Allergy Drug Targets·Manuela Battaglia, Maria Grazia Roncarolo
Dec 8, 2006·Annual Review of Immunology·Albert BendelacLuc Teyton
Feb 6, 2007·Nature Genetics·Jun YamanouchiPere Santamaria
Jun 21, 2007·European Journal of Immunology·Megan S FordLi Zhang
Nov 6, 2007·Nature Immunology·Katsuto TakenakaJayne S Danska
Jun 14, 2008·Journal of Autoimmunity·Margaret A Jordan, Alan G Baxter
Mar 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mark A WalletRoland Tisch
Apr 17, 2009·The New England Journal of Medicine·Patrick ConcannonGerald T Nepom
May 12, 2009·Nature Genetics·Jeffrey C BarrettUNKNOWN Type 1 Diabetes Genetics Consortium
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manabu ArakiLinda S Wicker
Feb 9, 2010·Journal of Autoimmunity·Véronique DugasSylvie Lesage
May 1, 2010·Nature·Jeffrey A BluestoneGeorge Eisenbarth
Jul 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan D KatzEdith M Janssen
Aug 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel A RebouletEdith M Janssen
Jun 7, 2011·Biochemical Pharmacology·Fulvio D'Acquisto, Tessa Crompton
Aug 31, 2011·Autoimmunity Reviews·Mara Kornete, Ciriaco A Piccirillo
Dec 6, 2011·Seminars in Immunology·Hye-Jung Kim, Harvey Cantor
Oct 16, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kritika KachapatiWilliam M Ridgway

❮ Previous
Next ❯

Citations

Apr 6, 2016·Immunology and Cell Biology·Erin E HillhouseSylvie Lesage
Jun 4, 2016·Journal of Autoimmunity·Emma E Hamilton-WilliamsRaymond J Steptoe
Aug 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roxanne CollinSylvie Lesage

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Naoto MatsukiSebastian Joyce
The Journal of Immunology : Official Journal of the American Association of Immunologists
Xavier MartinezLinda A Sherman
The Journal of Immunology : Official Journal of the American Association of Immunologists
Evgueni A IvakineJ S Danska
© 2021 Meta ULC. All rights reserved