Ideal target arterial pressure after control of bleeding in a rabbit model of severe traumatic hemorrhagic shock: results from volume loading-based fluid resuscitation

The Journal of Surgical Research
Xiao-Gang ZhaoJian-An Wang

Abstract

Previously reported ideal target mean arterial pressure (MAP) after control of bleeding in traumatic hemorrhagic shock (THS) requires further verification in more clinically related models. The authors explored this issue via gradient volume loading without vasopressor therapy. As certain volume loading can induce secretion of atrial natriuretic peptide (ANP), which has been shown to be protective, the authors also observed its potential role. Fifty male New Zealand rabbits were submitted to 1.5 h of uncontrolled THS (with another eight rabbits assigned to the sham group). After bleeding control, treated rabbits were randomly (n = 10, respectively) resuscitated with blood and Ringer lactate (1:2) to achieve target MAP of 50, 60, 70, 80, and 90 mm Hg within 1 h. During the following 2 h, they were resuscitated toward baseline MAP. Rabbits were observed until 7 h. After resuscitation, infused fluid was lower and oxidative stress injury was milder in the 70 mm Hg group. Fluid volume loaded during the initial hour after hemostasis was negatively correlated with pH, oxygen saturation, and base excess at the end of resuscitation. It also correlated positively with proinflammatory responses in bronchoalveolar lavage fluid at 7 h and 7...Continue Reading

References

Nov 14, 1997·The Annals of Thoracic Surgery·H SatoJ Vinten-Johansen
Aug 26, 2000·Peptides·L V González BoscN A Vidal
Sep 16, 2000·Current Opinion in Nephrology and Hypertension·S S Waikar, G M Chertow
Oct 4, 2005·The Journal of Clinical Investigation·Takahiro KatoMark A Sussman
Jan 12, 2007·The Journal of Trauma·Homer C TienFrederick D Brenneman
Sep 25, 2012·Lancet·Russell L GruenRonald V Maier
Oct 16, 2012·Journal of the American College of Surgeons·John Alfred Carr
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Apr 13, 2013·The Journal of Surgical Research·Eric J LeyAli Salim
Apr 23, 2013·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnRolf Rossaint
Apr 24, 2013·The Journal of Trauma and Acute Care Surgery·George KasotakisUNKNOWN Inflammation and Host Response to Injury Investigators
May 30, 2013·Critical Care : the Official Journal of the Critical Care Forum·Shou-yin JiangXiao-gang Zhao
Aug 21, 2013·The Journal of Surgical Research·Miniwan TulafuMakoto Tomita
Sep 27, 2013·The New England Journal of Medicine·John A Myburgh, Michael G Mythen
Dec 12, 2013·Critical Care : the Official Journal of the Critical Care Forum·João M SilvaLuiz M Sá Malbouisson
Feb 21, 2014·The Journal of Trauma and Acute Care Surgery·Jae Hyuk LeeHeajin Chung
Feb 25, 2014·Critical Care Medicine·Guillaume TachonJacques Duranteau
Mar 19, 2014·The New England Journal of Medicine·James A Russell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.