PMID: 15374364Nov 1, 1992Paper

Idebenone in senile dementia of Alzheimer type: a multicentre study

Archives of Gerontology and Geriatrics
U SeninM Fioravanti

Abstract

Idebenone is a new cerebro-active drug, effective in dementia disorders, particularly indicated in primary degenerative dementias, i.e. Alzheimer's disease. This new molecule acts as an electron trapper and a free radical scavenger protecting mitochondrial membranes from lipid peroxidation. A multicentric, double-blind trial of idebenone (45 mg twice daily orally) vs. placebo was carried out on 102 elderly patients affected by Alzheimer-type dementia of mild or moderate severity. Idebenone was administered for 4 consecutive months, 45 mg twice daily. Clinical evaluations were performed at the time of enrollment (t0) and monthly thereafter (t30, t60, t90 and t120) and at follow-up (t150 ). Tolerability to idebenone treatment was good and was associated with a statistically significant improvement of memory, attention and behaviour. It is worthwhile noting that these cognitive and behavioral findings were observed after the first month of treatment with enhancement evident in the following period.

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Citations

Nov 26, 1999·The New England Journal of Medicine·R Mayeux, M Sano
Dec 8, 2009·Neuropsychiatric Disease and Treatment·Meredith SpindlerClaire Henchcliffe
Mar 26, 2014·Neuroscience Bulletin·Zhichun Chen, Chunjiu Zhong
Dec 7, 2010·Free Radical Biology & Medicine·Magali Dumont, M Flint Beal
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Apr 10, 2013·Free Radical Biology & Medicine·Rajnish K Chaturvedi, M Flint Beal
Oct 25, 2011·Biochimica Et Biophysica Acta·Patrizia Mecocci, Maria Cristina Polidori
Sep 30, 2014·Journal of Bioenergetics and Biomembranes·Sausan Jaber, Brian M Polster
Jun 18, 2016·Oxidative Medicine and Cellular Longevity·Alexey V LokhmatikovArmen Y Mulkidjanian
Jan 5, 2019·Journal of the American Society of Nephrology : JASN·Rainer SchreiberKarl Kunzelmann
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Joanna WojsiatUrszula Wojda
Apr 14, 2016·The International Journal of Neuroscience·Aslina Pahrudin ArroziSuzana Makpol
May 12, 2009·Neuroscience and Behavioral Physiology·K V Voronkova, M N Meleshkov
Feb 20, 2019·Frontiers in Neuroscience·Xiu-Yun ZhaoQuan-Hong Ma
Dec 10, 2020·International Journal of Molecular Sciences·Haider ManzarM Francesca Cordeiro
Oct 29, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew Gleason, Ashley I Bush
Mar 2, 2021·EBioMedicine·Aarti SinghMichelangelo Campanella
Jun 3, 2021·International Journal of Molecular Sciences·Chanchal SharmaSang Ryong Kim
Oct 2, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Nilima PradhanArti Singh

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