PMID: 15374366Nov 1, 1992Paper

Idebenone in the treatment of multi-infarct dementia: a randomised, double-blind, placebo controlled multicentre trial

Archives of Gerontology and Geriatrics
B BergamascoR Coppi

Abstract

A controlled double blind randomised open multicentre study was carried out on 104 patients with multi-infarct dementia (MID) from a mild to a moderate degree. The patients were randomly assigned to balanced blocks in each center and treated for 90 days either with idebenone (CV-2619) 90 mg/daily or placebo, after a 2-week turn-in period. The Gottfries Rating Scale, SCAG, Rey's A Figure Test, Rey's 15 Words Test, Token Test, Verbal Fluidity Test and the Blessed Dementia Test were used for assessment. The data were statistically analyzed using parametric and non-parametric tests. Seven patients were excluded (5 idebenone + 2 placebo) after a few days treatment, for reasons not related to drug administration; therefore, 97 patients were assessed for efficacy and 104 for tolerability. A certain placebo effect was found in the examination results but it never achieved the efficacy levels of idebenone. The latter is particularly effective for improving recent and remote memory, attention, orientation, vigilance and verbal comprehension and the effects continued even after a month of placebo treatment. There were no important adverse reactions and neither laboratory parameters nor clinical vital signs were significantly altered.

References

Dec 1, 1977·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·E De RenziP Previdi
Jul 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·G BlessedM Roth
Dec 1, 1982·Archives of Gerontology and Geriatrics·C G GottfriesG Steen

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Citations

Feb 19, 2010·The Cochrane Database of Systematic Reviews·Clare DonnellanNav Sharma
May 18, 2012·The Cochrane Database of Systematic Reviews·Jing ZhangMing Liu
Aug 8, 2013·Depression and Anxiety·Holger CramerGustav Dobos
Jun 2, 2016·Health Technology Assessment : HTA·Carl J HeneghanTom Jefferson
Oct 30, 2013·The Cochrane Database of Systematic Reviews·Nanthiya PravitsitthikulJonathan C Craig
Jul 18, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·L S Chutko, S Yu Surushkina
May 1, 1996·Postgraduate Medical Journal·P Skaife, A N Kingsnorth

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