PMID: 2501446Jul 1, 1989Paper

Identical peptides recognized by MHC class I- and II-restricted T cells

The Journal of Experimental Medicine
D L PerkinsM L Gefter

Abstract

Previous data from many groups show that both class I and class II-restricted T cells recognize short synthetic peptides in the context of their respective MHC molecules (9-18), all of the peptides described to date are restricted to only a single class of MHC molecules; however, structural homology between the class I and II MHC molecules and the use of similar TCRs by class I and II-restricted T cells suggest that antigen recognition mechanisms are similar in both systems. To directly compare antigen recognition in the two systems, we analyzed peptides for the ability to function in both a class I and II-restricted system and found that seven of seven individual peptides tested stimulate both class I and II-restricted T cell responses. In addition, two of the peptides can function in different species stimulating both human class I and murine class II T cell responses. Thus, the process of T cell recognition of antigen in the context of MHC molecules was highly conserved in evolution not only between the class I and class II MHC systems, but also between the murine and human species.

References

Feb 20, 1987·Science·J G GuilletM L Gefter
Jan 1, 1986·Annual Review of Immunology·M KronenbergN Shastri
Jan 1, 1985·Annual Review of Immunology·M M Davis
Aug 1, 1983·The Journal of Experimental Medicine·R ShimonkevitzH Grey
Apr 1, 1984·European Journal of Immunology·W Haas, H von Boehmer
Jan 1, 1982·Hybridoma·L L LanierN L Warner

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Citations

Nov 6, 1990·Journal of Immunological Methods·R Busch, J B Rothbard
Jan 1, 1992·Molecular Aspects of Medicine·M Baines, A Ebringer
Jan 1, 1994·Immunology Today·J A Habeshaw
Jun 1, 1991·Research in Immunology·F M Brodsky
Oct 1, 1989·Current Opinion in Immunology·J B Rothbard
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K L RockB Benacerraf
Sep 11, 1992·Proceedings of the National Academy of Sciences of the United States of America·L D FaloK L Rock
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·W ChenM A Cheever
Dec 1, 1994·The Journal of Experimental Medicine·G IkonomidisD A Portnoy
May 10, 2000·Microbiology and Immunology·K KakugawaH Yamagishi
Aug 15, 1998·Vox Sanguinis·M K Gjertsen, G Gaudernack
Dec 15, 1996·The Journal of Clinical Investigation·S J KrinzmanP W Finn
Jan 1, 1991·International Reviews of Immunology·Y Paterson
Jan 1, 1991·Critical Reviews in Biochemistry and Molecular Biology·T P Levine, B M Chain
Jul 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire M TullyTeresa Lambe
Nov 1, 2007·Clinical Pharmacology and Therapeutics·I G OvsyannikovaG A Poland
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather D HickmanWilliam H Hildebrand
Nov 1, 1991·European Journal of Immunology·D L PerkinsM L Gefter

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