Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

PloS One
Jesmond DalliCharles N Serhan

Abstract

Maresin conjugates in tissue regeneration (MCTR) are a new family of evolutionarily conserved chemical signals that orchestrate host responses to promote tissue regeneration and resolution of infections. Herein, we identified the novel MCTR3 and established rank order potencies and matched the stereochemistries of MCTR1, MCTR2 and MCTR3 using material prepared by total organic synthesis and mediators isolated from both mouse and human systems. MCTR3 was produced from endogenous substrate by E. coli activated human macrophages and identified in sepsis patients. Each of the three synthetic MCTR dose-dependently (1-100nM) accelerated tissue regeneration in planaria by 0.6-0.9 days. When administered at the onset or peak of inflammation, each of the MCTR promoted resolution of E. coli infections in mice. They increased bacterial phagocytosis by exudate leukocytes (~15-50%), limited neutrophil infiltration (~20-50%), promoted efferocytosis (~30%) and reduced eicosanoids. MCTR1 and MCTR2 upregulated human neutrophil and macrophage phagocytic responses where MCTR3 also proved to possess potent actions. These results establish the complete stereochemistry and rank order potencies for MCTR1, MCTR2 and MCTR3 that provide novel resolution...Continue Reading

References

Oct 8, 1999·Emerging Infectious Diseases·P S MeadR V Tauxe
Sep 2, 2004·The Journal of Biological Chemistry·Jesper Z Haeggström
Jan 28, 2006·Cell·Alejandro Sánchez Alvarado
Sep 23, 2011·Chemical Reviews·Jesper Z Haeggström, Colin D Funk
Feb 10, 2012·The Journal of Biological Chemistry·Bengt Samuelsson
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Driss El KebirJános G Filep
Jan 12, 2013·Science·Ira Tabas, Christopher K Glass
Mar 19, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesmond DalliCharles N Serhan
May 28, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Niccolò TerrandoLars I Eriksson
Jun 12, 2013·Current Opinion in Pharmacology·Charles N Serhan, Nan Chiang
Sep 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rodrigo MarconJoão B Calixto
Nov 20, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bibiana RiusJoan Clària
Oct 18, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jesmond DalliCharles N Serhan
Feb 26, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesmond DalliCharles N Serhan

❮ Previous
Next ❯

Citations

Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jesmond DalliCharles N Serhan
Jan 6, 2017·Nature Reviews. Rheumatology·Mauro PerrettiLucy V Norling
Jan 15, 2017·Biochimie·Ondrej Kuda
Mar 1, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nan ChiangCharles N Serhan
May 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeevan Kumar Jadapalli, Ganesh V Halade
Feb 18, 2019·International Immunology·Tomoaki IshiharaMakoto Arita
May 10, 2019·Journal of Leukocyte Biology·Yulia Y TyurinaValerian E Kagan
Jun 13, 2019·Stem Cells Translational Medicine·Mario RomanoAntonio Recchiuti
Jan 15, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles N Serhan
Oct 8, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charlotte C JouveneCharles N Serhan
Nov 16, 2016·Future Medicinal Chemistry·Andreas Koeberle
Oct 6, 2017·Organic & Biomolecular Chemistry·Karoline Gangestad PrimdahlAnders Vik
Dec 4, 2020·International Immunopharmacology·Rong ZhuangZhongqiu Lu
Aug 15, 2017·Molecular Aspects of Medicine·Charles N SerhanJesmond Dalli
Apr 30, 2021·Pharmacology & Therapeutics·Dipak PanigrahyKhosrow Kashfi
May 18, 2021·Frontiers in Physiology·Alessandra MazzocchiCarlo Agostoni
Jun 29, 2021·Frontiers in Immunology·Christa DeckerGabrielle Fredman
Sep 10, 2019·Chemical Research in Toxicology·Adriano B Chaves-FilhoSayuri Miyamoto
Feb 2, 2022·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jamie D KraftEmma Börgeson

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
NMR

Software Mentioned

II Viewer
BZ
FlowJo
ImageJ

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jesmond DalliCharles N Serhan
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Charles N SerhanNicos A Petasis
Proceedings of the National Academy of Sciences of the United States of America
Jesmond DalliCharles N Serhan
Prostaglandins, Leukotrienes, and Essential Fatty Acids
Paul C NorrisCharles N Serhan
© 2022 Meta ULC. All rights reserved