Identification and analysis of a glutamatergic local interneuron lineage in the adult Drosophila olfactory system.

Neural Systems & Circuits
Abhijit DasVeronica Rodrigues

Abstract

The antennal lobe of Drosophila is perhaps one of the best understood neural circuits, because of its well-described anatomical and functional organization and ease of genetic manipulation. Olfactory lobe interneurons - key elements of information processing in this network - are thought to be generated by three identified central brain neuroblasts, all of which generate projection neurons. One of these neuroblasts, located lateral to the antennal lobe, also gives rise to a population of local interneurons, which can either be inhibitory (GABAergic) or excitatory (cholinergic). Recent studies of local interneuron number and diversity suggest that additional populations of this class of neurons exist in the antennal lobe. This implies that other, as yet unidentified, neuroblast lineages may contribute a substantial number of local interneurons to the olfactory circuitry of the antennal lobe. We identified and characterized a novel glutamatergic local interneuron lineage in the Drosophila antennal lobe. We used MARCM (mosaic analysis with a repressible cell marker) and dual-MARCM clonal analysis techniques to identify this novel lineage unambiguously, and to characterize interneurons contained in the lineage in terms of structure...Continue Reading

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Citations

Jul 12, 2013·Annual Review of Neuroscience·Rachel I Wilson
Jun 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wendy W Liu, Rachel I Wilson
Sep 5, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cynthia M Solek, Marc Ekker
Nov 15, 2012·Developmental Biology·Abhijit DasVolker Hartenstein
Nov 2, 2014·Frontiers in Cellular Neuroscience·Nicolás Palacios-PradoAlberto E Pereda
Nov 5, 2019·Science Advances·Rashmit KaurThomas Hummel

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Methods Mentioned

BETA
Flow Cytometry

Software Mentioned

ImageJ Photoshop
Amira
DVGLUT

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