Identification and analysis of the N(6)-methyladenosine in the Saccharomyces cerevisiae transcriptome.

Scientific Reports
Wei ChenLiqing Zhang

Abstract

Knowledge of the distribution of N(6)-methyladenosine (m(6)A) is invaluable for understanding RNA biological functions. However, limitation in experimental methods impedes the progress towards the identification of m(6)A site. As a complement of experimental methods, a support vector machine based-method is proposed to identify m(6)A sites in Saccharomyces cerevisiae genome. In this model, RNA sequences are encoded by their nucleotide chemical property and accumulated nucleotide frequency information. It is observed in the jackknife test that the accuracy achieved by the proposed model in identifying the m(6)A site was 78.15%. For the convenience of experimental scientists, a web-server for the proposed model is provided at http://lin.uestc.edu.cn/server/m6Apred.php.

References

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Citations

Feb 26, 2016·Journal of Biomolecular Structure & Dynamics·Wei ChenHao Lin
Oct 27, 2016·Molecular Genetics and Genomics : MGG·Wei ChenHao Lin
Oct 11, 2016·PloS One·Shunian XiangZhirong Sun
Mar 4, 2017·Journal of Cellular Biochemistry·Wenqiang WeiShaoping Ji
Nov 1, 2018·Current Drug Metabolism·Wei ChenDianchuan Jin
Dec 28, 2016·Non-coding RNA·Wei Chen, Hao Lin
Jun 6, 2018·Frontiers in Microbiology·Jidong ZhangWei Chen
Jul 1, 2018·Genes·Francesco MorenaSabata Martino
Jan 2, 2019·BMC Bioinformatics·Yiqian Zhang, Michiaki Hamada
Jul 14, 2020·Current Genomics·Rajiv G GovindarajBalachandran Manavalan
Mar 21, 2019·Frontiers in Microbiology·Wei DangJianhong Lu
Dec 15, 2020·Briefings in Functional Genomics·Chunyan AoQuan Zou
May 22, 2020·Computational and Structural Biotechnology Journal·Fu-Ying DaoHao Lin
Jul 17, 2020·Computational and Structural Biotechnology Journal·Lian LiuJia Meng
Feb 13, 2021·NAR Genomics and Bioinformatics·Jun Wang, Liangjiang Wang
Jul 1, 2021·Molecular Therapy. Nucleic Acids·Dawei RongXuehao Wang
Aug 31, 2021·Journal of Biomolecular Structure & Dynamics·Shengli ZhangYunyun Liang
Oct 15, 2020··Hejie ZhouZhenyu Yue

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Methods Mentioned

BETA
MeRIP-seq

Software Mentioned

BLAST
libsvm
WebLogo
WEKA

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