Identification and Antibiotic-Susceptibility Profiling of Infectious Bacterial Agents: A Review of Current and Future Trends.

Biotechnology Journal
Gaetano MaugeriAna C A Roque

Abstract

Antimicrobial resistance is one of the most worrying threats to humankind with extremely high healthcare costs associated. The current technologies used in clinical microbiology to identify the bacterial agent and profile antimicrobial susceptibility are time-consuming and frequently expensive. As a result, physicians prescribe empirical antimicrobial therapies. This scenario is often the cause of therapeutic failures, causing higher mortality rates and healthcare costs, as well as the emergence and spread of antibiotic resistant bacteria. As such, new technologies for rapid identification of the pathogen and antimicrobial susceptibility testing are needed. This review summarizes the current technologies, and the promising emerging and future alternatives for the identification and profiling of antimicrobial resistance bacterial agents, which are expected to revolutionize the field of clinical diagnostics.

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Citations

Jul 10, 2020·Lab on a Chip·Rathina Kumar ShanmugakaniSaurabh Mehta
Sep 13, 2020·Clinical Chemistry·Eric M RansomCarey-Ann D Burnham
Aug 8, 2020·Frontiers in Cellular and Infection Microbiology·Antti VasalaOlli H Laitinen
Jan 26, 2020·Micromachines·Maria Laura ColuccioNatalia Malara
Jan 24, 2021·Briefings in Bioinformatics·Dropen ShekaPaul M K Gordon
Jan 6, 2021·Journal of Global Antimicrobial Resistance·Greta RoncaratiMaria Carla Re
Jan 21, 2021·International Journal of Molecular Sciences·Simone RentschlerHans-Peter Deigner
Oct 23, 2020·Nature Communications·Daniel C SpencerHywel Morgan
Apr 5, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Andrew HendersonGunnar Kahlmeter
Nov 23, 2021·Frontiers in Medicine·Huiying ZhaoChristopher W Seymour
Dec 9, 2021·Microbiology Spectrum·András KállaiÁkos M Lőrincz

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Methods Mentioned

BETA
FRET
Assay
PCR
nucleic acid amplification
biosensors
biosensor
X-ray
chip
NMR
surface-enhanced Raman scattering

Software Mentioned

Biolog
GeneWEAVE
IRIDICA
oCelloScope
Verigene
FilmArray
Accelerate
Genefluidics
PLEXID
OmniLog ID system

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