Identification and assignment of function to the genes of Aspergillus fumigatus expressed at 37 degrees C

The Journal of Eukaryotic Microbiology
Jata ShankarP Usha Sarma

Abstract

Aspergillus fumigatus, a fungal pathogen, causes a spectrum of allergic and invasive disorders. In order to rapidly identify genes of this fungus relevant for pathogenesis and as potential antifungal drug targets, 125 expressed sequence tags (ESTs) were generated from 200 phage clones of a non-normalized cDNA library. Out of a novel 68 ESTs, 45 were assigned putative functions based on the sequence similarity. The identities of some of these genes suggest that they may be involved in pathogenesis or autoimmune reactions. Additional genes were identified that are possible targets for the development of antifungal drugs or that may be of use in diagnosing fungal infections.

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Citations

Jan 1, 2005·Indian Journal of Clinical Biochemistry : IJCB·Jata ShankarP Usha Sarma
Sep 1, 2006·Indian Journal of Clinical Biochemistry : IJCB·Poonam GautamP Usha Sarma
Oct 4, 2011·Indian Journal of Clinical Biochemistry : IJCB·P Usha Sarma
Apr 3, 2012·Indian Journal of Clinical Biochemistry : IJCB·Preetida J BhetariyaSarma P Usha
Feb 18, 2016·Biotechnology Research International·Shraddha TiwariJata Shankar
Apr 22, 2017·Indian Journal of Clinical Biochemistry : IJCB·Usha P SarmaAnupam Varma
Feb 29, 2020·MicrobiologyOpen·Xiangyu DengJun Li
Apr 9, 2005·Revista iberoamericana de micología·Aitor RementeriaJavier Garaizar

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