Identification and characterisation of angiotensin II receptor subtypes in human brain

European Journal of Pharmacology
J M BarnesN M Barnes

Abstract

Autoradiographic and homogenate binding studies using the radioligand, [125I]angiotensin II, identified a heterogeneous distribution of specific binding sites (defined by angiotensin II, 1.0 microM) throughout the human forebrain. Highest AT receptor densities were detected in the paraventricular nucleus, median eminence, substantia nigra, putamen and caudate nucleus (2.4, 1.2, 1.0, 0.30 and 0.24 fmol/mg tissue equivalent, respectively). The AT1 receptor antagonist, losartan (1.0 microM) competed for the majority of the specific binding. [125I]Angiotensin II-specific binding (although not consistently above non-specific binding levels) was also detected in various other brain regions (e.g. amygdala, entorhinal cortex, frontal cortex, hippocampus, inferior colliculus, nucleus accumbens, parietal cortex, periaquaductal grey, superior colliculus, striate cortex, temporal cortex, thalamus). In the presence of losartan (1.0 microM), angiotensin II, saralasin, losartan and PD123177 competed for [125I]angiotensin II binding to membranes prepared from the cerebellum or substantia nigra with a rank order of affinity; angiotensin II = saralasin > PD123177 > losartan. In the presence of PD123177 (1.0 microM), the rank order of affinity of...Continue Reading

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Citations

Aug 3, 2005·Cellular and Molecular Neurobiology·Juan M Saavedra
Mar 22, 2002·European Journal of Pharmacology·Paul R Gard
Dec 10, 1999·Regulatory Peptides·J M Saavedra
Oct 1, 1993·British Journal of Pharmacology
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Mar 2, 2018·Journal of Neuroinflammation·M Florencia IulitaHélène Girouard
Nov 12, 2005·Journal of Clinical Psychopharmacology·Marc HertzmanMartha Kern
Jan 14, 1999·Journal of Hypertension·J ZhuoF A Mendelsohn
Feb 17, 2018·Journal of Neuro-oncology·Alexander Perdomo-PantojaTalia Wegman-Ostrosky
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Mar 27, 1995·Brain Research·D P MacGregorF A Mendelsohn
Feb 4, 1999·Regulatory Peptides·A M AllenF A Mendelsohn
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May 22, 2021·AJNR. American Journal of Neuroradiology·A ChammasI J Namer
Apr 20, 2005·Regulatory Peptides·Juan M SaavedraMiroslava Macova

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