Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4

Bioorganic & Medicinal Chemistry Letters
Christopher BlackburnPrakash Raman

Abstract

Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of the 4-aryl group led to active compounds. In two cases racemates were resolved and the S enantiomers shown to have higher potencies.

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Citations

Jun 10, 2010·American Journal of Physiology. Endocrinology and Metabolism·Alaric FalconAndreas Stahl
Oct 25, 2011·International Journal of Medical Sciences·Julia KrammerRobert Ehehalt
Aug 1, 2007·Future Lipidology·Douglas G MashekRosalind A Coleman
May 15, 2015·Annual Review of Nutrition·Satya DashGary F Lewis
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katharina Schreck, Matthias F Melzig
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Feb 13, 2009·ChemMedChem·Stéphanie KolbEmmanuelle Braud
Feb 18, 2014·British Journal of Pharmacology·Stephen P H AlexanderUNKNOWN CGTP Collaborators
Jul 23, 2021·Progress in Lipid Research·Rahul MallickAsim K Duttaroy
Mar 13, 2009·Progress in Lipid Research·Isabelle NiotPhilippe Besnard
Nov 17, 2009·Biochemical Pharmacology·Angel SandovalConcetta C Dirusso
Oct 13, 2011·Biochimica Et Biophysica Acta·Xiaoyue Pan, M Mahmood Hussain

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