PMID: 6114001Jun 1, 1981Paper

Identification and characterization of a beta 1-adrenergic receptor in the rat Sertoli cell

Molecular and Cellular Endocrinology
J J HeindelS J Strada

Abstract

The beta 1-adrenergic receptor of rat Sertoli cells was characterized by measurement of the ability of adrenergic receptor agonists and antagonists to stimulate cAMP accumulation in Sertoli cells from 18-day-old rats. Epinephrine, norepinephrine and isoproterenol stimulate cAMP accumulation in Sertoli cells which is not additive with maximal doses of FSH and which is age-dependent, beta-antagonists, alprenolol, hydroxybenzylpindolol or propranolol inhibit isoproterenol-induced cAMP accumulation while alpha-adrenergic antagonists have no effect. Dobutamine and soterenol stimulated cAMP accumulation to a greater extent than albuterol and metoproterenol. Finally, the stimulatory effects of isoproterenol and zinterol are both more sensitive to inhibition by beta 1-antagonists than by beta 2-antagonists. Taken together these data indicate the presence of a beta 1-adrenergic receptor in Sertoli cells which is coupled to adenylate cyclase.

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Citations

Nov 1, 1983·Developmental Biology·F EusebiM Stefanini
Jan 1, 1984·Molecular and Cellular Endocrinology·H AttramadalV Hansson
Jan 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·L EikvarV Hansson
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A L KierszenbaumJ P Perkins
Nov 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A L FavarettoJ A Antunes-Rodrigues
Jan 1, 1989·Toxicologic Pathology·J J Heindel, K A Treinen
May 1, 1990·Andrologia·M B CamposR S Calandra
Jan 1, 1984·Experimental Eye Research·S W Koh, G J Chader
Oct 15, 1981·Biochemical and Biophysical Research Communications·R Madhubala, P R Reddy
Mar 30, 1988·Biochemical and Biophysical Research Communications·M BreuillerG Pointis

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