PMID: 8613142Jan 1, 1996Paper

Identification and characterization of a new major histocompatibility complex class I gene in carp (Cyprinus carpio L.)

Immunogenetics
S H van ErpR J Stet

Abstract

In this study we report the finding of three representatives of a new group of major histocompatibility complex class I sequences in carp: Cyca-12 (Cyca-UA1*01), a full-length cDNA; Cyca-SP1 (Cyca-UAW1), a polymerase chain reaction (PCR) fragment from cDNA; and Cyca-G11 (Cyca-UA1*02), a partial genomic clone. Comparison of the amino acid sequences of Cyca-12, Cyca-SP1, and Cyca-G11 with classical and non-classical class I sequences from other species shows considerable conservation in regions that have been shown to be involved in maintaining the structure and function of class I molecules. The genomic organization of Cyca-12 has been elucidated by analysis of a partial genomic clone (Cyca-G11, in combination with PCR amplifications on genomic DNA of a homozygous individual. Although the genomic organization is similar to that found in class I genes from other species, the 3' untranslated region contains an intron which is unprecedented in class I genes, and intron 2 is exceptionally large (+/-14 kilobases). Southern blot analysis indicates the presence of multiple related sequences. In phylogenetic analyses, the Cyca-UA sequences cluster with class I genes from zebrafish and Atlantic salmon, indicating that the ancestral gene ...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H OnoJ Klein
Dec 5, 1992·Journal of Molecular Biology·E A SturaI A Wilson
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K HashimotoY Kurosawa
Apr 1, 1992·Computer Applications in the Biosciences : CABIOS·D G HigginsR Fuchs
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M F FlajnikM Kasahara
May 20, 1991·Journal of Molecular Biology·M A SaperD C Wiley
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K HashimotoY Kurosawa
Jan 1, 1988·Annual Review of Immunology·A F Williams, A N Barclay
Jun 11, 1986·Nucleic Acids Research·G von Heijne
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Mar 1, 1995·Developmental and Comparative Immunology·B DixonR J Stet
Jan 1, 1995·Developmental and Comparative Immunology·J C Koumans-van DiepenJ H Rombout
Mar 22, 1995·Proceedings. Biological Sciences·F FigueroaJ Klein
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·U A BetzJ Klein
Jan 1, 1994·Annual Review of Immunology·S M ShawarR R Rich
Jan 1, 1994·Developmental and Comparative Immunology·J C Koumans-van DiepenJ H Rombout
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·S Bartl, I L Weissman
Jul 1, 1993·Developmental and Comparative Immunology·J H RomboutA J Taverne-Thiele
Jan 1, 1993·Immunogenetics·H OnoJ Klein
Jan 1, 1993·Immunogenetics·H OnoJ Klein

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Citations

Jan 1, 1996·Immunogenetics·S H van ErpR J Stet
May 28, 2005·Current Rheumatology Reports·Bruce M Rothschild
Mar 1, 1995·Developmental and Comparative Immunology·B DixonR J Stet
Nov 1, 1995·Developmental and Comparative Immunology·P N RodriguesR J Stet
Jun 22, 2005·Developmental and Comparative Immunology·Heidi B T HuttenhuisJan H W M Rombout
Jul 25, 2000·Developmental and Comparative Immunology·U GrimholtR J Stet
Jul 27, 2001·Developmental and Comparative Immunology·A B AntaoV G Chinchar
Nov 1, 1996·Developmental and Comparative Immunology·J D HansenL Du Pasquier
May 8, 1999·Veterinary Immunology and Immunopathology·A EstepaJ M Coll
Dec 30, 1999·Veterinary Immunology and Immunopathology·T NakanishiM Ototake
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·L F CadavidD I Watkins
Mar 19, 2014·Developmental and Comparative Immunology·Hayley DirscherlJill L O de Jong
Oct 21, 2006·Fish & Shellfish Immunology·Alberto CuestaMaria Angeles Esteban
Oct 1, 1996·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S H van ErpR J Stet
Oct 24, 1998·Biochemical and Biophysical Research Communications·H YamaguchiK Hashimoto
Apr 28, 2019·Cells·Takuya Yamaguchi, Johannes M Dijkstra
Sep 16, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Carla PiazzonMaria Forlenza
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Corine P KruiswijkRené J M Stet
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B P ShumP Parham
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuhiko AoyagiTeruyuki Nakanishi
Jun 7, 2002·Fish & Shellfish Immunology·Chun XiaMitsuru Ototake
Nov 3, 2004·Fish & Shellfish Immunology·Eva OttováSerge Morand

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