Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Andrea FaedoAlessandro Bulfone

Abstract

By using a custom-made array containing cDNAs preferentially expressed in the mouse embryonic telencephalon (Porteus et al. [1992] Brain Res Mol Brain Res 12:7-22; and Alessandro Bulfone, unpublished data), we studied the gene expression profile of the Dlx1/Dlx2(-/-) subpallium and Pax6(-/-) pallium. We identified a transcript corresponding to Unigene Cluster Mm.94021 and rat Evf-1, which is down-regulated in the Dlx1/Dlx2(-/-) subpallium and up-regulated in the Pax6(-/-) pallium. Here, we report the expression pattern of this transcript, designated mouse Evf1 (mEvf1), in the prenatal forebrain of wild-type, Dlx1/Dlx2(-/-) and Pax6(-/-) mice using RNA in situ hybridization and reverse transcriptase-polymerase chain reaction. In the wild-type forebrain mEvf1 expression is restricted to the ventral thalamus, hypothalamus, and subpallial telencephalon (caudal, lateral, and medial ganglionic eminences and septal primordia), whereas it is down-regulated in the Dlx1/Dlx2(-/-) subpallium (mainly in caudal, lateral, and medial ganglionic eminences), and up-regulated in the Pax6(-/-) lateral and ventral pallium at embryonic day 12.5 and in the dorsal, lateral, and ventral pallium at embryonic day 14.5.

References

Aug 1, 1996·Genomics·T McGuinnessJ L Rubenstein
Feb 12, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J K LiuJ L Rubenstein
Oct 12, 1999·The Journal of Comparative Neurology·D D EisenstatJ L Rubenstein
Feb 13, 2001·Neuron·S W Wilson, J L Rubenstein
Nov 20, 2001·EMBO Reports·J S Mattick
Nov 21, 2001·Nature Reviews. Neuroscience·O Marín, J L Rubenstein
Dec 6, 2001·Cerebral Cortex·Thorsten StühmerJohn L R Rubenstein
Feb 28, 2002·Current Opinion in Neurobiology·Carol Schuurmans, François Guillemot
Dec 4, 2002·Nature Reviews. Neuroscience·Murielle RalluGord Fishell
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert A DrewellEdward B Lewis
Dec 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Esther BaeRobert A Drewell
Jan 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hynek WichterleArturo Alvarez-Buylla
Feb 21, 2003·Current Opinion in Neurobiology·Kenneth Campbell
Sep 25, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John S Mattick
Feb 14, 2004·Molecular and Cellular Neurosciences·Marzia PereraGiovanni Levi
Jun 9, 2004·Gene Expression Patterns : GEP·Jhumku D Kohtz, Gord Fishell

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Citations

May 22, 2009·Genome Research·Michael HillerPeter F Stadler
Jan 20, 2010·BMC Developmental Biology·Keiko Numayama-TsurutaNoriko Osumi
Jul 19, 2011·PLoS Genetics·Sonja C VernesSimon E Fisher
Oct 27, 2010·Cellular and Molecular Life Sciences : CMLS·A GlejzerS Wislet-Gendebien
Aug 13, 2011·Trends in Genetics : TIG·Ulf Andersson Orom, Ramin Shiekhattar
Feb 19, 2011·Current Opinion in Genetics & Development·Ulf Andersson Ørom, Ramin Shiekhattar
Nov 28, 2009·Trends in Biotechnology·Jan GorodkinWalter L Ruzzo
Apr 1, 2011·The Journal of Comparative Neurology·Bei WangJohn L R Rubenstein
Sep 17, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Meixia Li, Li Liu
Dec 16, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·UNKNOWN Athanasius F Bompfünewerer ConsortiumSebastian Will
Jun 17, 2021·Molecular Biology and Evolution·Giovanni LeviNicolas Narboux-Nême

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