Identification and characterization of a novel member of the dystrobrevin gene family

FEBS Letters
A A PucaB Franco

Abstract

A new member of the dystrobrevin gene family was identified using a bioinformatics approach. Sequence analysis indicates that this gene, named DTN-B, is highly homologous to the rabbit A0, the previously described dystrobrevin (DTN), Torpedo 87 kDa and to the C-terminus of dystrophin. The coiled-coil domain, shown to be the site of interaction between dystrobrevins and dystrophin, is highly conserved. Immunostaining studies indicate that DTN-B and DTN expression is absent in affected muscle fibers from DMD patients and carriers.

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Citations

Apr 7, 2000·Brain Research. Brain Research Reviews·M F Mehler
Aug 6, 2003·Neuromuscular Disorders : NMD·K J JonesK N North
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y MizunoL M Kunkel
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Jul 27, 2007·Muscle & Nerve·Yuji MizunoLouis M Kunkel
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Apr 5, 2000·The Journal of Biological Chemistry·G PilusoV Nigro
Nov 6, 2003·Journal of Cell Science·P MacioceT C Petrucci

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