PMID: 8610176Apr 2, 1996Paper

Identification and characterization of a RING zinc finger gene (C-RZF) expressed in chicken embryo cells

Proceedings of the National Academy of Sciences of the United States of America
P TranqueV P Mauro

Abstract

To identify changes in gene expression that occur in chicken embryo brain (CEB) cells as a consequence of their binding to the extracellular matrix molecule cytotactin/tenascin (CT/TN), a subtractive hybridization cloning strategy was employed. One of the cDNA clones identified was predicted to encode 381 amino acids and although it did not resemble any known sequences in the nucleic acid or protein data bases, it did contain the sequence motif for the cysteine-rich C3HC4 type of zinc finger, also known as a RING-finger. This sequence was therefore designated the chicken-RING zinc finger (C-RZF). In addition to the RING-finger, the C-RZF sequence also contained motifs for a leucine zipper, a nuclear localization signal, and a stretch of acidic amino acids similar to the activation domains of some transcription factors. Southern analysis suggested that C-RZF is encoded by a single gene. Northern and in situ hybridization analyses of E8 chicken embryo tissues indicated that expression of the C-RZF gene was restricted primarily to brain and heart. Western analysis of the nuclear and cytoplasmic fractions of chicken embryo heart cells and immunofluorescent staining of chicken embryo cardiocytes with anti-C-RZF antibodies demonstrat...Continue Reading

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Citations

Aug 29, 1998·The Plant Journal : for Cell and Molecular Biology·Y H CheongJ C Hong
Dec 6, 2000·Protein Science : a Publication of the Protein Society·P Mahon, A Bateman
Oct 13, 2010·BMC Genomics·Ignat DrozdovAjay M Shah
Aug 15, 2012·Cellular and Molecular Life Sciences : CMLS·Qiang ZhangDahai Zhu
Aug 23, 2000·The Journal of Cell Biology·L JiangJ C Rogers
Nov 17, 2010·The FEBS Journal·Xianglan JinDahai Zhu
Mar 17, 2010·Traffic·Jeffrey P BocockAnn H Erickson
May 6, 2015·Progress in Biophysics and Molecular Biology·Matthias Zebisch, E Yvonne Jones
Nov 19, 2002·Developmental Biology·Annette G M BorchersJulie C Baker
Oct 30, 2015·RNA Biology·Vincent P Mauro, Daiki Matsuda
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J C SmithM Tada

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