Identification and characterization of a TAB1 gene involved in innate immunity of amphioxus (Branchiostoma belcheri)

Gene
Denghua YinPing Jin

Abstract

Transforming growth factor-β activated kinase-1 (TAK1) is an essential regulator in toll-like receptor (TLR), tumor necrosis factor (TNF) and interleukin-1 (IL-1) signaling pathways, and plays very important roles in animal innate immunity. TAK1-binding protein, TAB1, can specifically regulate the activation of TAK1. However, the TAB1 gene in amphioxus has not yet been identified to date. In this study, we identified and characterized a TAB1 gene from Branchiostoma belcheri (designed as AmphiTAB1). Our results showed that the full-length cDNA of AmphiTAB1 is 2281bp long with an open reading frame (ORF) of 1659bp that encodes a predicted protein of 553 amino acids containing a typical PP2Cc domain. Phylogenetic analysis indicated that the AmphiTAB1 gene was located between invertebrates and vertebrates, suggesting that the AmphiTAB1 gene is a member of the TAB1 gene family. Real-time PCR analysis indicated that the AmphiTAB1 was ubiquitously and differentially expressed in six investigated tissues (gills, hepatic cecum, intestine, muscles, notochord and gonad). After lipopolysaccharide stimulation, the expression of AmphiTAB1 was significantly up-regulated at 6h, which shows that AmphiTAB1 may be involved in the host immune resp...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Nov 1, 1994·Trends in Biochemical Sciences·R J Davis
Jun 1, 1994·Trends in Biochemical Sciences·K J Blumer, G L Johnson
Apr 1, 1993·Trends in Biochemical Sciences·E Nishida, Y Gotoh
Apr 1, 1996·Current Opinion in Cell Biology·R Treisman
Jun 1, 1996·Current Opinion in Immunology·B Su, M Karin
Mar 28, 1998·The EMBO Journal·H ShibuyaN Ueno
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J SchultzC P Ponting
Jul 16, 2003·Biochemical and Biophysical Research Communications·Koichiro OnoMasayuki Tsuchiya
Nov 18, 2005·Journal of Molecular Biology·Kieron BrownGraham M T Cheetham
Aug 2, 2006·The Biochemical Journal·Sarah H ConnerDaan M F Van Aalten
May 15, 2007·Oncogene·A AdhikariZ J Chen
Jan 12, 2010·The International Journal of Biochemistry & Cell Biology·Marene Landström
Aug 28, 2010·Science·Roberto BonasioJürgen Liebig
Nov 5, 2011·Nucleic Acids Research·Ivica LetunicPeer Bork
Feb 7, 2012·The EMBO Journal·Shalini PathakDaan Mf van Aalten
Sep 4, 2012·IUBMB Life·Liang DaiPeter C F Cheung
May 15, 2013·Trends in Immunology·Adebusola A AjibadeRong-Fu Wang
Feb 19, 2014·The Journal of Cell Biology·Sho MoriokaJun Ninomiya-Tsuji

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Citations

Jan 10, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinyu YanShengfeng Huang
Jan 3, 2021·Developmental and Comparative Immunology·Wenjun WangShuo Ding

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