Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk

Journal of Neuroscience Research
S S KuoI W Caras


A novel cDNA, brain-associated tyrosine kinase (Batk), was isolated from a rat hippocampal library and appears to encode a new member of the Csk subfamily of non-receptor protein tyrosine kinases, with 52% overall amino acid identity to rat Csk. Batk resembles kinases of the Src family in that it contains a Src homology 2 (SH2) domain and an SH3 domain, followed by a tyrosine kinase domain. Analysis of incompletely spliced Batk cDNAs suggests that the genomic structure of Batk is similar to that of Csk with identical exon/intron boundaries. Batk also shows significant homology (86% overall amino acid identity) to the recently described human megakaryocyte-specific Matk. Although Batk is 41 amino acids shorter than Matk, Southern blot analysis suggests that Batk might be a rat homolog of Matk. Batk is predominantly expressed in the brain, with lower expression in the spleen and undetectable expression in other tissues. In situ hybridization and Northern blot analysis show that Batk is widely distributed throughout the adult brain, being primarily expressed in neurons, including those of the hippocampus and cortex. In contrast, embryos appear to have markedly decreased expression levels. Analysis of postnatal day 1 brain suggests...Continue Reading


Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Oct 1, 1992·Molecular and Cellular Biology·H SabeH Hanafusa
Jan 25, 1991·Cell·L C CantleyS Soltoff
Nov 1, 1987·Molecular and Cellular Biology·J M Le BeauG Walter
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A F Wilks
Jan 1, 1985·Annual Review of Biochemistry·T Hunter, J A Cooper
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C A RossS H Snyder
Jun 12, 1986·Nature·L M SmithL E Hood
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jan 22, 1982·Nucleic Acids Research·S M Mount
May 1, 1993·Neuron·D M ValenzuelaG D Yancopoulos


Jun 7, 1996·Biochimica Et Biophysica Acta·M T Brown, J A Cooper
May 1, 2008·The Journal of Biological Chemistry·Jindong XuXian-Min Yu
Aug 1, 1996·DNA and Cell Biology·R BlouinG Grondin
Jan 1, 1997·Annual Review of Immunology·J B Bolen, J S Brugge
Nov 15, 2007·Journal of Neurochemistry·Hiroaki MitsuhashiShoichi Ishiura
Mar 8, 2005·Experimental Cell Research·Yuji Nakayama, Naoto Yamaguchi
Oct 4, 2005·Biochimica Et Biophysica Acta·Yuh-Ping ChongHeung-Chin Cheng
May 11, 2013·Nature Reviews. Cancer·Philip J Hogg
Jan 17, 1997·The Journal of Biological Chemistry·S Zrihan-LichtH Avraham
Jul 11, 2001·The Journal of Biological Chemistry·C BougeretH Avraham
Feb 27, 2004·The Journal of Biological Chemistry·Yuh-Ping ChongHeung-Chin Cheng
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J D BjorgeD J Fujita

Related Concepts

CSK protein, human
Matk protein, rat
Nerve Tissue Proteins
Protein Tyrosine Kinase
Molecular Probes
Homologous Sequences, Amino Acid
Src-Family Kinases

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