Abstract
CEPU-1/Neurotrimin is a neuronal glycoprotein thought to play a role in axon guidance and cell-cell recognition. It is a member of the IgLON family, has three C2 domains, and is attached to the plasma membrane by a GPI-anchor. We report here the characterisation of an alternatively-spliced isoform of CEPU-1 that is secreted. This isoform, termed CEPU-Se, is coexpressed with CEPU-1 in retina, cerebellum, and DRG neurons. In the cerebellum CEPU-1/CEPU-Se is expressed predominantly on granule cells and in the molecular layer. Divalent but not monovalent CEPU-Se interacts with CEPU-1 and other IgLONs, suggesting that the ability of CEPU-Se to modify the activity of the IgLON family may require an additional cofactor. CEPU-Se does not support the outgrowth of DRG neurons or the extension of established growth cones; however, neurite outgrowth on laminin is unaffected by CEPU-Se. Our data suggest that CEPU-Se may act to modulate the ability of CEPU-1, LAMP, and OBCAM to influence neurite outgrowth.
References
Jun 24, 1994·Science·S MayorF R Maxfield
May 1, 1995·The Journal of Cell Biology·A Gorodinsky, D A Harris
Jun 1, 1995·Current Biology : CB·R RizzutoT Pozzan
Aug 1, 1995·Neuron·A F PimentaP Levitt
Nov 11, 1996·The Journal of Comparative Neurology·A F PimentaP Levitt
Feb 1, 1997·The European Journal of Neuroscience·G A Clarke, D J Moss
Mar 1, 1997·Brain Research. Molecular Brain Research·K A HancoxP L Jeffrey
Jun 1, 1997·The European Journal of Neuroscience·T BrümmendorfU Treubert
Oct 23, 1997·Journal of Neuroscience Research·R C HenkeP L Jeffrey
Jun 20, 1998·The Journal of Cell Biology·T HarderK Simons
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·F GalbiatiM P Lisanti
Sep 2, 1998·Nature·R Varma, S Mayor
Dec 19, 1998·Journal of Neurobiology·D M LangC A Stuermer
Dec 31, 1998·Molecular Biology Reports·G B ten DamB Wieringa
Mar 13, 1999·The Journal of Biological Chemistry·N FunatsuS Maekawa
Apr 10, 1999·Molecular Biology of the Cell·S IlangumaranD C Hoessli
May 20, 1999·The Journal of Cell Biology·A MargT Brümmendorf
Jul 20, 1999·The Journal of Biological Chemistry·M TruppC F Ibáñez
Oct 20, 1999·The Journal of Cell Biology·P W JanesA I Magee
Nov 27, 1999·Neuroscience Research·Y KimuraH Tanaka
Jan 19, 2000·Nature·K HongM Poo
Apr 25, 2000·Neuron·M G TanseyE M Johnson
May 4, 2000·Molecular Biology of the Cell·A K KenworthyM Edidin
Oct 24, 2000·Brain Research. Molecular Brain Research·A P LodgeD J Moss
Citations
Feb 8, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sachiv ShethSarah M Dry
Jul 31, 2012·PloS One·Angela W S LeeMichael K E Schäfer
Jul 16, 2008·Journal of Neuroscience Research·Dora Krizsan-AgbasPeter G Smith
Jan 20, 2005·Gene·Stefan StammHermona Soreq
Jun 1, 2005·Experimental Cell Research·A Díaz-LópezC De Juan
Dec 21, 2010·Brain Research·Mohammed AkeelDiana Moss
Dec 23, 2014·Autonomic Neuroscience : Basic & Clinical·M Mónica Brauer, Peter G Smith
Jun 11, 2005·Molecular and Cellular Neurosciences·Michael SchäferThomas Brümmendorf
Nov 20, 2002·Journal of Neurochemistry·Vemuganti L Raghavendra RaoRobert J Dempsey
Oct 28, 2016·Behavioural Brain Research·Timur MazitovEero Vasar
Dec 11, 2003·Molecular and Cellular Neurosciences·Kathie L EaglesonPat Levitt
Aug 5, 2009·FEMS Microbiology Letters·Sawaki TadaYutaka Kashiwagi
May 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Shouqiang ChengEngin Özkan
Feb 9, 2020·Fertility and Sterility·Toral P ParikhWilliam H Catherino
Jul 22, 2004·Journal of Cell Science·James ReedDiana Moss
Jul 10, 2003·Brain Research·Seiji MiyataShohei Maekawa