Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients

Psychoneuroendocrinology
Monika ZabaUlrike Schmidt

Abstract

Analysis of the function of the hypothalamic-pituitary-adrenal (HPA)-axis in patients suffering from posttraumatic stress disorder (PTSD) has hitherto produced inconsistent findings, inter alia in the Trier Social Stress Test (TSST). To address these inconsistencies, we compared a sample of 23 female PTSD patients with either early life trauma (ELT) or adult trauma (AT) or combined ELT and AT to 18 age-matched non-traumatized female healthy controls in the TSST which was preceded by intensive baseline assessments. During the TSST, we determined a variety of clinical, psychological, endocrine and cardiovascular parameters as well as expression levels of four HPA-axis related genes. Using a previously reported definition of HPA-axis responsive versus non-responsive phenotypes, we identified for the first time two clinically and biologically distinct HPA-axis reactivity subgroups of PTSD. One subgroup ("non-responders") showed a blunted HPA-axis response and distinct clinical and biological characteristics such as a higher prevalence of trauma-related dissociative symptoms and of combined AT and ELT as well as alterations in the expression kinetics of the genes encoding for the mineralocorticoid receptor (MR) and for FK506 binding...Continue Reading

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Citations

Feb 29, 2016·Psychiatry Research. Neuroimaging·Jacklynn M FitzgeraldK Luan Phan
Jul 28, 2016·Stress : the International Journal on the Biology of Stress·Meghan E Pierce, Laurel M Pritchard
Jun 18, 2017·The Journal of Orthopaedic and Sports Physical Therapy·David M Walton, James M Elliott
Jul 20, 2019·Stress : the International Journal on the Biology of Stress·Vadim TseilikmanDaniela Jezova
Feb 14, 2020·The Journal of Nervous and Mental Disease·Lynne LiebermanStewart A Shankman
Jul 4, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ulrike Schmidt, Theo Rein
Jul 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Anthony S ZannasDavid R Rubinow
Oct 1, 2020·Cellular and Molecular Life Sciences : CMLS·Anne-Kathrin GellnerRené Hurlemann
May 14, 2020·Stress : the International Journal on the Biology of Stress·Alexey SarapultsevVadim Tseilikman
May 8, 2020·Translational Psychiatry·Alexander VerbitskyNanyin Zhang
May 6, 2016·Journal of Psychopharmacology·Zeng-Liang JinJie Xiong
Jul 9, 2020·Revista da Associação Médica Brasileira·Jun-Cheng GuoTao Huang
Jun 1, 2017·Clinical Psychology : a Publication of the Division of Clinical Psychology of the American Psychological Association·Dorthie CrossBekh Bradley
Dec 22, 2017·Journal of the Endocrine Society·Odelia CooperShlomo Melmed
Feb 10, 2018·Psychoneuroendocrinology·Andrew W ManigaultSally S Dickerson
May 23, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Céleste M ChevalierUlrike Schmidt
Aug 2, 2021·The Journal of Nervous and Mental Disease·Kayla A Kreutzer, Stephanie M Gorka

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