PMID: 15375572Sep 18, 2004Paper

Identification and characterization of human CXXC10 gene in silico

International Journal of Oncology
Masuko Katoh, Masaru Katoh

Abstract

CXXC4 gene encodes Dishevelled-binding protein, functioning as a negative regulator of WNT - beta-catenin signaling pathway. CXXC5, encoding CXXC finger (PHD domain) protein, is the paralog of CXXC4. CXXC6, MLL, DNMT1, ASXL1, ASXL2, and ASXL3 are cancer-associated genes belonging to the CXXC gene family. Here, we identified and characterized CXXC10 (CXXL4L or CXXC6L) gene by using bioinformatics. Complete coding sequence of human CXXC10 cDNA was determined by assembling AI438961 EST, AC073046.7 genome sequence, BX492895 EST, and MGC22014 5'-truncated cDNA. CXXC10 gene products derived from nucleotide positions 428-739 and 811-3624 were designated CXXC10-1 and CXXC10-2, respectively. CXXC10-1 (103 aa) was homologous to CXXC4 and CXXC6 within the CXXC domain. CXXC10-2 (937 aa) was homologous to CXXC6, and KIAA1546. Complete coding sequence of KIAA1546 cDNA was determined by assembling BF900449 EST, IMAGE3536481 partial cDNA, and KIAA1546 5'-truncated cDNA (AB046766.1). LCXH1 domain (codon 1-273 of CXXC10-2) and LCXH2 domain (codon 778-854 of CXXC10-2) were conserved among CXXC10-2, KIAA1546, and CXXC6. CXXC4 and KIAA1546 genes were closely linked in head to head manner with an interval of about 700 kb. CXXC10 locus at 2p13.1, CXX...Continue Reading

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