Identification and characterization of macaque CD89 (immunoglobulin A Fc receptor)

Immunology
Kenneth A RogersR Attanasio

Abstract

The interaction of the immunoglobulin A (IgA) molecule with its specific cellular receptor is necessary to trigger a variety of effector functions able to clear IgA-opsonized antigens. The human IgA-specific Fc receptor, FcalphaRI or CD89, is expressed on cells of the myeloid lineage. Recently, CD89 homologues have been identified in rats and cattle. Because non-human primates represent well established models for a variety of human diseases and for the testing of immunotherapeutic strategies, we cloned and sequenced cDNAs corresponding to the CD89 gene from rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques. Macaque sequences of full-length CD89 consist of five exons of length identical to the corresponding human CD89 exons. The rhesus and cynomolgus macaque derived amino acid sequences are highly homologous to each other (99.3% identity) and exhibit 86.5% and 86.1% identity to the human counterpart, respectively. Transfection of HeLa cells with plasmids containing the cloned macaque cDNAs resulted in the expression of surface molecules recognized by an anti-human CD89 antibody. Five splice variants were identified in rhesus macaques. Three of the five variants are similar to described human CD89 splice vari...Continue Reading

References

Apr 1, 1992·Human Genetics·E J KremerC R Maliszewski
Dec 1, 1990·The Journal of Experimental Medicine·C R MaliszewskiL Shen
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H B FleitJ C Unkeless
Sep 15, 1996·The Biochemical Journal·R J PleassJ M Woof
Oct 10, 1996·Gene·T J ReterinkM R Daha
Dec 22, 1999·Clinical and Experimental Immunology·R AttanasioH M McClure
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C S HahnR P Taylor
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B D WinesP M Hogarth
Jun 22, 2001·Critical Reviews in Oncology/hematology·M Dechant, T Valerius
Jan 30, 2002·Trends in Biotechnology·Blaise Corthésy
Jun 26, 2002·Molecular Biology and Evolution·Kenta SumiyamaShintaroh Ueda
Aug 8, 2002·Current Pharmaceutical Biotechnology·Leonard G Presta
Oct 18, 2002·Trends in Molecular Medicine·Renato C MonteiroMichelle Arcos-Fajardo
Dec 24, 2002·Nature Medicine·Wei LuJean-Marie Andrieu
Jan 14, 2003·Annual Review of Immunology·Renato C Monteiro, Jan G J Van De Winkel
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·He XuAllan D Kirk
Aug 30, 2003·International Immunopharmacology·Yulia VugmeysterEleanor Canova-Davis
Dec 3, 2003·Immunogenetics·Takako MaruokaMasanori Kasahara
Mar 19, 2004·Immunology·H Craig MortonJenny M Woof
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul J TackenJoseph J Batenburg

❮ Previous
Next ❯

Citations

Oct 19, 2006·Immunogenetics·Franco ScinicarielloRoberta Attanasio
Sep 12, 2008·Journal of Leukocyte Biology·Kun QianJianming Wu
May 10, 2011·Chemosphere·Roberta AttanasioH Edward Murray
Aug 16, 2005·Veterinary Immunology and Immunopathology·H Craig Morton
Dec 20, 2005·The Journal of Pathology·Jenny M Woof, Michael A Kerr
Nov 26, 2013·Veterinary Immunology and Immunopathology·Lisa M BergeronGraeme Bainbridge
Jun 2, 2010·The Journal of Allergy and Clinical Immunology·Roland KolbeckAnthony J Coyle
Sep 24, 2004·Immunology·Jenny M Woof, Michael A Kerr
Jul 31, 2018·AIDS Research and Human Retroviruses·Ester LopezAmy W Chung
Apr 14, 2006·Veterinary Research·Veerle SnoeckEric Cox
Jul 29, 2005·Immunological Reviews·Jenny M Woof, Jiri Mestecky
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth A RogersRoberta Attanasio
Jun 17, 2018·Mucosal Immunology·Tiffany Hensley-McBainNichole R Klatt
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael DechantThomas Valerius
Dec 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Halina M TristP Mark Hogarth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.