Identification and characterization of novel adeno-associated virus isolates in ATCC virus stocks.

Journal of Virology
Michael SchmidtJohn A Chiorini

Abstract

Adeno-associated viruses (AAVs) depend on a helper virus for efficient replication. To identify novel AAV isolates, we screened a diverse set of virus isolates for the presence of AAV DNA. AAVs found in 10 simian adenovirus isolates showed greater than 96% homology to AAV1 and AAV6 but had distinct biological properties. Two representatives of this group, AAV(VR-195) and AAV(VR-355), were studied in more detail. While the novel AAVs had high sequence homologies and required sialic acid for cell binding and transduction, differences were observed in lectin competition, resulting in distinct tropisms in human cancer cell lines.

References

Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·M D HogganW P Rowe
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R J SamulskiN Muzyczka
Feb 1, 1983·Journal of Virology·A SrivastavaK I Berns
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T R FlotteB J Carter
Mar 23, 2001·The Journal of Biological Chemistry·R W WaltersJ Zabner
Aug 13, 1965·Science·R W ATCHISONW M HAMMON
Sep 27, 2003·Journal of Virology·A KernJ A Kleinschmidt
May 28, 2004·Journal of Virology·Michael SchmidtJohn A Chiorini
Jan 18, 2006·Human Gene Therapy·Michael P SeilerChristine L Halbert

❮ Previous
Next ❯

Citations

Oct 3, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kim Van VlietRichard O Snyder
May 18, 2010·Nature Medicine·Melodie L WellerJohn A Chiorini
Aug 30, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xuan ShenMark A Kay
Sep 12, 2013·Human Gene Therapy Methods·Eduardo LabordaRamon Alemany
Mar 19, 2009·ILAR Journal·Christine Gagliardi, Bruce A Bunnell
Jun 14, 2013·Journal of Virology·Brittney L GurdaMavis Agbandje-McKenna
May 16, 2006·Journal of Virology·Michael Schmidt, John A Chiorini
Feb 13, 2009·Journal of Virology·F Curtis HewittR Jude Samulski
Mar 16, 2007·Journal of Virology·Kevin NashNicholas Muzyczka
Feb 18, 2014·Future Virology·Lauren M Drouin, Mavis Agbandje-McKenna
May 24, 2011·The Canadian Journal of Cardiology·Kleopatra RaptiRoger J Hajjar
May 19, 2009·Journal of Virological Methods·Kim Van VlietRichard O Snyder
Jun 25, 2010·The Journal of General Virology·Yan LiZhengli Shi
Oct 5, 2016·Experimental Neurology·Carlos B Mantilla
Jul 11, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhijian WuR Jude Samulski
Dec 5, 2008·Gene Therapy·L H VandenbergheG Gao
Nov 20, 2019·International Journal of Molecular Sciences·Lucia ZiccardiMonica Varano
Jun 1, 2021·Progress in Retinal and Eye Research·Catherine BottoDeniz Dalkara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.