Identification and characterization of novel enhanced cell penetrating peptides for anti-cancer cargo delivery

Oncotarget
Xiguang ZhangAngelita Rebollo

Abstract

Cell penetrating peptides (CPP) are able cross the membrane and to transport cargos, presenting a great potential in drug delivery and diagnosis. In this paper, we have identified novel natural or synthetic CPPs. We have validated their rapid and efficient time and dose-dependent penetration, the absence of toxicity, the intracellular localization and the stability to proteases degradation, one of the main bottlenecks of peptides. Moreover, we have associate a cargo (an interfering peptide blocking the association of the serine/threonine phosphatase PP2A to its inhibitor, the oncogene SET) to the new generated shuttles and showed that they new bi-functional peptides keep the original properties of the shuttle and, in addition, are able to induce apoptosis due to the properties of the cargo. The CPPs identified in this study have promising perspectives for future anti-cancer drug delivery.

References

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Citations

Aug 14, 2020·PloS One·Chang Zhi DongAngelita Rebollo
Mar 20, 2019·Scientific Reports·Leticia Dominguez-BerrocalAngelita Rebollo
Sep 19, 2019·Expert Opinion on Drug Delivery·Kaido Kurrikoff, Ülo Langel

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Methods Mentioned

BETA
flow cytometry
FACS
fluorescence microscopy
xenograft
FCS

Software Mentioned

Clinprot
Mut3DPT
FOLD
PEPscan
PEP
Flex analysis
- FOLD
Flex

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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