PMID: 9541569May 16, 1998Paper

Identification and characterization of nucleotide sequence differences in three virulence-associated genes of listeria monocytogenes strains representing clinically important serotypes

Current Microbiology
A Vines, B Swaminathan

Abstract

Listeria monocytogenes is a Gram-positive, facultative intracellular bacterium that causes invasive, often fatal, disease in susceptible hosts. As a foodborne pathogen, the bacterium has emerged as a significant public health problem and has caused several epidemics in the United States and Europe. Three serotypes (1/2a, 1/2b, 4b) of L. monocytogenes are responsible for nearly 95% of all reported cases of human listeriosis. L. monocytogenes serotype 4b has caused all well-characterized foodborne epidemic outbreaks in North America and Europe between 1981 and 1993. However, most of the genetic studies to characterize virulence factors of L. monocytogenes have been done by using serotypes 1/2a and 1/2c. In this investigation, we examined three virulence-associated genes (hly encoding listeriolysin, plcA encoding phosphotidylinositol-specific phospholipase C, and inlA encoding internalin) of two serotype 4b and two serotype 1/2b strains. We chose these virulence-associated genes on the basis of published sequence differences among strains from Listeria subgroups containing serotypes 1/2a and 1/2c versus 4b, respectively. They correspond to sequence homologies that include very highly conserved (hlyA), highly conserved (plcA) and m...Continue Reading

Citations

Jan 4, 2001·International Journal of Food Microbiology·M S Chae, H Schraft
Sep 6, 2000·Journal of Applied Microbiology·A K KaratzasE P Kets
Feb 2, 2002·Applied and Environmental Microbiology·C JacquetJ Rocourt
Dec 9, 2003·Applied and Environmental Microbiology·Monica K BoruckiDouglas R Call
Jul 24, 2004·Infection and Immunity·Eliane MilohanicJean-Louis Gaillard
Nov 28, 2002·Journal of Clinical Microbiology·Dmitriy VolokhovVladimir Chizhikov
Aug 31, 2002·Journal of Clinical Microbiology·Steven CaiMartin Wiedmann
Nov 15, 2002·Journal of Food Protection·Sophia Kathariou
Jul 18, 2020·Frontiers in Microbiology·Youwei FengXin'an Jiao

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