Identification and characterization of Serpulina pilosicoli isolates recovered from the blood of critically ill patients.

Journal of Clinical Microbiology
D J TrottDavid J Hampson

Abstract

The phenotypic and genetic characteristics of spirochetes isolated from the blood of one U.S. and six French patients with severe clinical disease or impaired immunity were examined. All spirochetes were anaerobic, weakly beta-hemolytic, positive for hippurate hydrolysis, and negative for beta-glucosidase activity. Cell lengths ranged from 4 to 8 microm, and each isolate had between 8 and 12 periplasmic flagella per cell. These features were consistent with the spirochetes' being Serpulina pilosicoli, the agent of intestinal spirochetosis. All isolates were positive in a PCR assay amplifying a portion of the S. pilosicoli 16S rRNA gene, and they all grouped with fecal isolates of S. pilosicoli in multilocus enzyme electrophoresis (MLEE). The blood isolates could be differentiated from each other by MLEE, although the U.S. and two French isolates were closely related. Apparently S. pilosicoli may translocate from the large intestine to establish spirochetemia. The clinical significance of this finding remains uncertain and requires further investigation.

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Citations

Apr 5, 2003·Journal of Medical Microbiology·Abdollah Jamshidi, David J Hampson
Jan 5, 2007·Journal of Gastroenterology and Hepatology·Adriana CalderaroCarlo Chezzi
Dec 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jin TanahashiShigeo Yokoyama
Oct 17, 2009·Microbiology·Ram Naresh, David J Hampson
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·M A MotalebN W Charon
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·C J BrookeT V Riley
Sep 22, 2011·Expert Reviews in Molecular Medicine·Judith Miklossy
Sep 17, 2013·Letters in Applied Microbiology·R Naresh, D J Hampson
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Aug 26, 1998·FEMS Microbiology Letters·E L HartlandD J Hampson
Jul 15, 2005·Journal of Food Protection·James L Smith
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Adriana CalderaroCarlo Chezzi
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