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Identification and characterization of the first ovothiol biosynthetic enzyme

Journal of the American Chemical Society

Jan 21, 2011

Andrea Braunshausen, Florian P Seebeck

Abstract

Ovothiols are histidine-derived thiols that were first isolated from marine invertebrates. We have identified a 5-histidylcysteine sulfoxide synthase (OvoA) as the first ovothiol biosynthetic enzyme and characterized OvoAs from Erwinia tasmaniensis and Trypanosoma cruzi . Homologous enz...read more

Mentioned in this Paper

Histidine
Genome
Enzymes, antithrombotic
Erwinia
Tertiary Protein Structure
Sulfoxides
Sulfhydryl Compounds
Methylhistidines
Enzymes for Treatment of Wounds and Ulcers
Carbon-Sulfur Ligases
41
Paper Details
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Identification and characterization of the first ovothiol biosynthetic enzyme

Journal of the American Chemical Society

Jan 21, 2011

Andrea Braunshausen, Florian P Seebeck

PMID: 21247153

DOI: 10.1021/ja109378e

Abstract

Ovothiols are histidine-derived thiols that were first isolated from marine invertebrates. We have identified a 5-histidylcysteine sulfoxide synthase (OvoA) as the first ovothiol biosynthetic enzyme and characterized OvoAs from Erwinia tasmaniensis and Trypanosoma cruzi . Homologous enz...read more

Mentioned in this Paper

Histidine
Genome
Enzymes, antithrombotic
Erwinia
Tertiary Protein Structure
Sulfoxides
Sulfhydryl Compounds
Methylhistidines
Enzymes for Treatment of Wounds and Ulcers
Carbon-Sulfur Ligases
41

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Chagas Disease

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. Discover the latest research on chagas disease here.

Chagas Disease

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Journal of the American Chemical Society

In vitro reconstitution of Mycobacterial ergothioneine biosynthesis

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Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol

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Christine E HandJohn F Honek
Paper Details
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  • Citations29
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