Identification and characterization of the lamprey high-mobility group box 1 gene.

PloS One
Yue PangQingwei Li

Abstract

High-mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, plays an important role in maintaining nucleosome structures, transcription, and inflammation. We identified a homolog of HMGB1 in the Japanese lamprey (Lampetra japonica). The Lampetra japonica HMGB1 gene (Lj-HMGB1) has over 70% sequence identity with its homologs in jawed vertebrates. Despite the reasonably high sequence identity with other HMGB1 proteins, Lj-HMGB1 did not group together with these proteins in a phylogenetic analysis. We examined Lj-HMGB1 expression in lymphocyte-like cells, and the kidneys, heart, gills, and intestines of lampreys before and after the animals were challenged with lipopolysaccharide (LPS) and concanavalin A (ConA). Lj-HMGB1 was initially expressed at a higher level in the heart, but after treatment with LPS and ConA only the gills demonstrated a significant up-regulation of expression. The recombinant Lj-HMGB1 (rLj-HMGB1) protein bound double-stranded DNA and induced the proliferation of human adenocarcinoma cells to a similar extent as human HMGB1. We further revealed that Lj-HMGB1 was able to induce the production of tumor necrosis factor-α (TNF-α), a pro-inflammatory mediator, in activated human acute monocytic leuk...Continue Reading

References

Jul 7, 1999·Biochimica Et Biophysica Acta·S KraussM D Brand
Aug 22, 2000·The Journal of Experimental Medicine·U AnderssonK J Tracey
Mar 14, 2001·Trends in Biochemical Sciences·J O Thomas, A A Travers
May 1, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lynda Stuart, Jeremy Hughes
Apr 4, 2003·Current Opinion in Genetics & Development·Alessandra Agresti, Marco E Bianchi
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Davorka MessmerNicholas Chiorazzi
Mar 1, 2005·Journal of Leukocyte Biology·Huan YangKevin J Tracey
Mar 24, 2005·The Journal of Biological Chemistry·Tzung-Chieh TsaiShow-Li Chen
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ingrid E DumitriuPatrizia Rovere-Querini
Jun 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zeev PancerMax D Cooper
Oct 11, 2005·Current Opinion in Immunology·James A Mahoney, Antony Rosen
Jan 24, 2006·General and Comparative Endocrinology·Stacia A SowerHiroshi Kawauchi
Jul 4, 2006·Journal of Molecular Biology·Katherine StottJean O Thomas
Oct 13, 2006·Journal of Leukocyte Biology·Ingrid E DumitriuPatrizia Rovere-Querini
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akihiro IshiiTsukasa Seya
May 1, 2007·Biochemical and Biophysical Research Communications·Naoko ItoShoji Odani
Sep 19, 2007·Current Opinion in Immunology·Chris T AmemiyaAgustin Zapata
Oct 10, 2007·Immunogenetics·Shigeyuki TsutsuiTasuku Watanabe
Nov 6, 2007·Immunological Reviews·Marco E Bianchi, Angelo A Manfredi
Jan 15, 2008·The International Journal of Biochemistry & Cell Biology·Dessislava TopalovaEvdokia A Pasheva
Apr 18, 2008·Briefings in Bioinformatics·Sudhir KumarKoichiro Tamura
Jul 5, 2008·Current Opinion in Immunology·Lara CampanaPatrizia Rovere-Querini
May 29, 2009·Nature·Peng GuoMax D Cooper
Feb 4, 2010·Biochimica Et Biophysica Acta·Michal Stros
Feb 4, 2010·Biochimica Et Biophysica Acta·Daolin TangMichael T Lotze
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huan YangKevin J Tracey
Feb 5, 2011·Nature·Baubak BajoghliThomas Boehm
Mar 23, 2011·Virulence·Lieselotte Vande WalleMohamed Lamkanfi
Apr 30, 2011·The Journal of Biological Chemistry·Xiang ZhaoHeikki Rauvala
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Darren G N CraigKenneth J Simpson
Aug 13, 2011·The Journal of Biological Chemistry·Huiqing HuangAnlong Xu

❮ Previous
Next ❯

Citations

May 23, 2014·Acta Biochimica Et Biophysica Sinica·Yinglun HanQingwei Li
May 3, 2014·Acta Biochimica Et Biophysica Sinica·Yinglun HanQingwei Li
May 20, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Chunhui ZhaoQingwei Li
Jul 11, 2014·Molecular Aspects of Medicine·Rui KangDaolin Tang
Feb 26, 2015·Immunology Letters·Yue PangQingwei Li
May 18, 2016·Antonie van Leeuwenhoek·Yingying LiQingwei Li

❮ Previous
Next ❯

Datasets Mentioned

BETA
HQ615991
AY578058

Methods Mentioned

BETA
PCR
electrophoretic mobility shift
electrophoresis
ELISA
Protein Assay
enzyme-linked immunosorbent assay

Software Mentioned

Basic Local Alignment Search Tool ( BLAST )
ExPASy
MEGA
ProtParam
Thermal Cycler Dice Real Time System
ClustalX

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.