PMID: 8955293Dec 1, 1996Paper

Identification and characterization of uvrA, a DNA repair gene of Deinococcus radiodurans

Journal of Bacteriology
H AgostiniK W Minton

Abstract

Deinococcus radiodurans is extraordinarily resistant to DNA damage, because of its unusually efficient DNA repair processes. The mtcA+ and mtcB+ genes of D. radiodurans, both implicated in excision repair, have been cloned and sequenced, showing that they are a single gene, highly homologous to the uvrA+ genes of other bacteria. The Escherichia coli uvrA+ gene was expressed in mtcA and mtcB strains, and it produced a high degree of complementation of the repair defect in these strains, suggesting that the UvrA protein of D. radiodurans is necessary but not sufficient to produce extreme DNA damage resistance. Upstream of the uvrA+ gene are two large open reading frames, both of which are directionally divergent from the uvrA+ gene. Evidence is presented that the proximal of these open reading frames may be irrB+.

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Citations

Jan 1, 1997·Annual Review of Microbiology·J R Battista
Dec 6, 2006·Molecular Genetics and Genomics : MGG·Che-Hung ShenMei-Kwei Yang
Oct 27, 1998·Nature Biotechnology·W Hendrickson
Nov 22, 2005·International Journal of Radiation Biology·U Pogoda de la VegaG Horneck
Jun 6, 2018·Extremophiles : Life Under Extreme Conditions·Lynda BeladjalJohan Mertens
Jun 24, 2008·Critical Reviews in Biochemistry and Molecular Biology·Melanie BlasiusUlrich Hübscher
May 2, 2003·Bioscience, Biotechnology, and Biochemistry·Shigeru KitayamaHiroshi Watanabe
Jul 25, 2007·FEMS Microbiology Letters·David J Schlesinger
Dec 15, 2012·Extremophiles : Life Under Extreme Conditions·Takefumi OnoderaIssay Narumi
Aug 7, 2018·Journal of Basic Microbiology·Harinder Singh
May 5, 2009·The Journal of Microbiology·Na-Rae Yun, Young Nam Lee
Oct 13, 2011·Molecular & Cellular Proteomics : MCP·Bhakti Basu, Shree Kumar Apte
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Dea Slade, Miroslav Radman

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