Abstract
We isolated Veph, a novel gene encoding a pleckstrin homology (PH) domain-containing protein from a mouse. Veph was strongly expressed in the embryonic brain, and its expression level gradually decreased in later stages. In situ hybridization analysis of sectioned embryo brains revealed that Veph was expressed exclusively in the ventricular zone. We then isolated a zebrafish orthologue of Veph (zVeph). As observed in the mouse gene, zVeph was expressed in the ventricular zone of developing brain and spinal cord. Blockage of zVeph expression by injection of zVeph-specific morpholino antisense oligo into zebrafish fertilized eggs resulted in a defect in the midbrain-hindbrain boundary and otic vesicle formation, suggesting the important function of zVeph in central nervous system (CNS) development. On the other hand, homozygous knockout mice of Veph showed no significant defect in the CNS, pointing to possible different functions of Veph between the zebrafish and mouse.
References
Feb 1, 1992·Current Opinion in Neurobiology·S K McConnell
Jan 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A InoueH Okamoto
Dec 31, 1993·Cell·S KraussP W Ingham
Jan 1, 1993·Annual Review of Neuroscience·C B Kimmel
Mar 11, 1993·Nucleic Acids Research·E Oxtoby, T Jowett
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Jan 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Shaw
Jun 12, 1998·The Journal of Comparative Neurology·A J BlaschkeJ Chun
Dec 5, 2000·Genetics·S N ProkopenkoH J Bellen
Mar 26, 2002·FEBS Letters·Mark A LemmonCharles S Abrams
Jun 4, 2002·Nature Reviews. Neuroscience·Bagirathy Nadarajah, John G Parnavelas
Mar 6, 2003·Developmental Biology·Ryo KuritaSumiko Watanabe
Citations
May 10, 2013·Molecular Biology Reports·C V A CollaresE A Donadi
Sep 19, 2006·Molecular and Cellular Biology·Chisako NakadaSumiko Watanabe
May 11, 2013·BioMed Research International·Yutaka NibuAnna Di Gregorio
Jun 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Premalatha ShathasivamTheodore J Brown
Aug 9, 2006·Journal of Neurochemistry·Steve PoirierNabil G Seidah
Aug 2, 2005·Developmental Cell·Aurelio A TelemanStephen M Cohen
Sep 7, 2005·Cell·Tamara Mikeladze-DvaliClaude Desplan
Mar 17, 2017·British Journal of Cancer·Premalatha ShathasivamTheodore J Brown
Dec 6, 2005·Parasitology Research·M A BakheitJ S Ahmed
Jan 21, 2006·Parasitology Research·J MirandaU Seitzer
Oct 18, 2005·The Journal of General Virology·Erwin van den BornEric J Snijder
Apr 29, 2020·Journal of Cellular Physiology·Xiaofeng ShiLei Li
Sep 25, 2017·Genetics, Selection, Evolution : GSE·Bin YangHendrik-Jan Megens
Oct 11, 2019·Cell Cycle·Hao FengNing Ning
Sep 11, 2019·Cell Communication and Signaling : CCS·Theodore J BrownMaurice J Ringuette
Jul 2, 2020·Journal of Hepatology·Pingping DongShe Chen