Identification and characterization of Arabidopsis indole-3-butyric acid response mutants defective in novel peroxisomal enzymes.

Genetics
Bethany K ZolmanBonnie Bartel

Abstract

Genetic evidence suggests that indole-3-butyric acid (IBA) is converted to the active auxin indole-3-acetic acid (IAA) by removal of two side-chain methylene units in a process similar to fatty acid beta-oxidation. Previous studies implicate peroxisomes as the site of IBA metabolism, although the enzymes that act in this process are still being identified. Here, we describe two IBA-response mutants, ibr1 and ibr10. Like the previously described ibr3 mutant, which disrupts a putative peroxisomal acyl-CoA oxidase/dehydrogenase, ibr1 and ibr10 display normal IAA responses and defective IBA responses. These defects include reduced root elongation inhibition, decreased lateral root initiation, and reduced IBA-responsive gene expression. However, peroxisomal energy-generating pathways necessary during early seedling development are unaffected in the mutants. Positional cloning of the genes responsible for the mutant defects reveals that IBR1 encodes a member of the short-chain dehydrogenase/reductase family and that IBR10 resembles enoyl-CoA hydratases/isomerases. Both enzymes contain C-terminal peroxisomal-targeting signals, consistent with IBA metabolism occurring in peroxisomes. We present a model in which IBR3, IBR10, and IBR1 ma...Continue Reading

References

Nov 26, 1984·Nucleic Acids Research·M Bevan
Jul 1, 1984·Physiological Reviews·G Wolf
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·B Bartel, G R Fink
Aug 16, 1996·Science·M J BennettK A Feldmann
Nov 14, 1997·The Plant Journal : for Cell and Molecular Biology·S Lebel-HardenackS R Grant
Jun 17, 1998·The Plant Journal : for Cell and Molecular Biology·S D Michaels, R M Amasino
Dec 5, 1998·The Journal of Biological Chemistry·B V GeisbrechtS J Gould
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Mar 11, 1999·The Plant Cell·R T DaviesB Bartel
Apr 23, 1999·The Journal of Biological Chemistry·H HayashiM Nishimura
Oct 16, 1999·The Plant Cell·T A Richmond, A B Bleecker
Nov 26, 1999·The Plant Journal : for Cell and Molecular Biology·M A HooksI A Graham
Mar 14, 2000·Current Opinion in Plant Biology·T Richmond, S Somerville
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·P J EastmondI A Graham
Jun 20, 2000·Plant Physiology·P NagpalJ W Reed
Jun 20, 2000·Plant Physiology·B E FromanK Dehesh
Jun 12, 2001·Journal of Molecular Biology·A M MursulaR K Wierenga
Sep 29, 2001·Plant Molecular Biology·S LeClere, B Bartel
Jan 5, 2002·Progress in Lipid Research·Ian A Graham, Peter J Eastmond
Jan 10, 2002·The Journal of Biological Chemistry·Dongyan ZhangHorst Schulz
Feb 16, 2002·Protein Science : a Publication of the Protein Society·Yvonne KallbergBengt Persson
Sep 17, 2002·European Journal of Biochemistry·Yvonne KallbergBengt Persson
Oct 9, 2002·The Plant Journal : for Cell and Molecular Biology·Martin FuldaErnst Heinz
Dec 7, 2002·Bioorganic & Medicinal Chemistry·Gautam Agnihotri, Hung-wen Liu

❮ Previous
Next ❯

Citations

Nov 4, 2009·Planta·Laura FattoriniMaria Maddalena Altamura
May 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kamil RuzickaJirí Friml
May 14, 2010·The Journal of Biological Chemistry·Valerie E PyeAnette Henriksen
Jun 3, 2010·Cold Spring Harbor Perspectives in Biology·Paul OvervoordeTom Beeckman
Apr 25, 2013·PloS One·Shang-Hui JinBing-Kai Hou
May 15, 2013·Journal of Experimental Botany·Michael SauerJürgen Kleine-Vehn
Apr 13, 2013·Journal of Experimental Botany·David A KorasickLucia C Strader
Jan 1, 2009·The Arabidopsis Book·Navneet KaurJianping Hu
Jun 25, 2014·Antioxidants & Redox Signaling·Peter Geigenberger, Alisdair R Fernie
Aug 14, 2012·Nature Chemical Biology·Bert De RybelTom Beeckman
Mar 30, 2011·Plant, Cell & Environment·Vanesa B TognettiFrank Van Breusegem
Jun 7, 2013·Plant, Cell & Environment·Xiang GaoYing-Tang Lu
Jun 24, 2014·The Arabidopsis Book·Yunde Zhao
Jul 5, 2013·Journal of Zhejiang University. Science. B·Anna Pick Kiong LingSobri Hussein
May 12, 2015·Current Biology : CB·Wei XuanTom Beeckman
Mar 2, 2011·Molecular Plant·Lucia C Strader, Bonnie Bartel
Jul 16, 2013·Plant Science : an International Journal of Experimental Plant Biology·Sarah K Kessel-VigeliusNicole Linka
Mar 23, 2011·Plant Science : an International Journal of Experimental Plant Biology·Sibu Simon, Jan Petrášek
Oct 16, 2007·Journal of Plant Physiology·Zsuzsanna KolbertLászló Erdei
Feb 24, 2006·Vitamins and Hormones·Shoji Mano, Mikio Nishimura
Sep 27, 2005·Current Opinion in Plant Biology·Alison Baker, Imogen Averil Sparkes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.