Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.

Genetics
Craig J CeolH R Horvitz

Abstract

The synthetic multivulva (synMuv) genes negatively regulate Ras-mediated vulval induction in the nematode Caenorhabditis elegans. The synMuv genes define three classes, A, B, and C, such that double mutants carrying mutations in genes of any two classes are multivulva. The class B synMuv genes include lin-35, a homolog of the retinoblastoma (Rb) tumor suppressor gene, as well as homologs of genes that function with Rb in transcriptional regulation. We screened for additional synMuv mutations using a strategy different from that of previous synMuv genetic screens. Some of the mutations we recovered affect new synMuv genes. We present criteria for assigning synMuv mutations into different genetic classes. We also describe the molecular characterization of the class B synMuv gene lin-65.

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Citations

Apr 4, 2007·Genes & Development·Eileen L BeallMichael R Botchan
Jun 13, 2012·Molecular and Cellular Biology·Peter W LewisMichael R Botchan
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Melissa M HarrisonH Robert Horvitz
Jul 8, 2008·Current Opinion in Cell Biology·Raphael SacherLucas Pelkmans
Apr 17, 2007·Developmental Biology·David S Fay, John Yochem
May 20, 2017·Biology Open·Mei-Hsin ChengJoseph S Lipsick
Nov 22, 2017·Molecular and Cellular Biology·Dharini van der HoevenJohn F Hancock
Dec 14, 2018·Journal of Developmental Biology·Hanna Shin, David J Reiner
Jun 13, 2008·The EMBO Journal·Tomohiro YamauchiShunsuke Ishii
Feb 10, 2019·The Journal of Cell Biology·Colin E DelaneyJan Padeken
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Valérie J RobertFrancesca Palladino
Mar 24, 2021·European Journal of Medicinal Chemistry·Pingyuan WangJia Zhou

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