Identification and clinical validation of metastasis-associated biomarkers based on large-scale samples in colon-adenocarcinoma.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Lei GuHong Zhou

Abstract

Distant metastasis is the main cause of death in patients with colon-adenocarcinoma(COAD). Due to the lack of effective molecular markers and treatment, the prognosis of patients with metastatic colon cancer is still rather poor. Metastatic related signature (MRS) of stage I and stage IV in colon cancer were identified from different cohorts. Univariate cox regression is used to analyze the relationship between MRS and the overall survival. L1000FWD and DGIdb databases are used to identify molecular drugs. Expression and functional experimental validation of the hub MRS were carried out. 16 MRS were identified, of which 14 MRS was significantly correlated with overall survival. Further functional enrichment analysis showed that MRS was significantly involved with important biological functions such as cell migration, and apoptosis. As important metastatic related genes, GSR, FAS and CYP1B1 have significant interaction with drug molecules. Further studies have confirmed that the expression of FAS and GSR is low, and inhibition of its expression can promote the metastasis of COAD. CYP1B1 expression is highly expressed, and inhibition of its expression can attenuate the malignant biological behavior of colon cancer. Our research c...Continue Reading

Citations

Jan 15, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Komi NambouManawa Anakpa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Siu Yu Zoe Lau
Journal of Palliative Medicine
Patrick J Coyne
Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates
M L Scannell
The Canadian Nurse
H Sproul
© 2021 Meta ULC. All rights reserved