PMID: 9190830Jun 1, 1997Paper

Identification and DNA sequence of the mobilization region of the 5-nitroimidazole resistance plasmid pIP421 from Bacteroides fragilis

Journal of Bacteriology
S Trinh, G Reysset

Abstract

The nucleotide sequence of the DNA mobilization region of the 5-nitroimidazole resistance plasmid pIP421, from strain BF-F239 of Bacteroides fragilis, was determined. It contains a putative origin of transfer (oriT) including three sets of inverted repeats and two sequences reminiscent of specific integration host factor binding sites. The product of the mobilization gene mob421 (42.2 kDa) is a member of the Bacteroides mobilization protein family, which includes the MobA of pBI143, NBUs, and Tn4555. Sequence similarity suggests that it has both oriT binding and nicking activities. The transfer frequency of pIP421 in a B. fragilis donor strain possessing a Tc(r) or Tc(r) Em(r)-like conjugative transposon was significantly enhanced by tetracycline. Moreover, the mobilization region of pIP421 confers the ability to be mobilized from Escherichia coli by an IncP plasmid.

References

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Citations

May 16, 2002·Periodontology 2000·Marilyn C Roberts
Dec 13, 2005·The Journal of Antimicrobial Chemotherapy·József SókiBrian I Duerden
Apr 22, 2016·The Open Dentistry Journal·Georgios KoukosDimitra Sakellari
Aug 4, 2012·Journal of Applied Oral Science : Revista FOB·Geisla Mary Silva SoaresMagda Feres
Jul 10, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A HaggoudM Moumni
Sep 12, 1998·Journal of Bacteriology·L A SitailoD W Hecht
Jul 11, 1998·Plasmid·C J SmithD P Bayley

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