Identification and estrogenic characterization of impurities in commercial bisphenol A diglycidyl ether (BADGE)

Chemosphere
Masanori TerasakiMasakazu Makino

Abstract

A sample of commercial BADGE was fractioned by HPLC and eight impurities including novel propyl derivatives (2), (5) and (6) were identified by NMR spectrometry, FAB-MS and GC-MS. The estrogenicity, both agonist and antagonist, of fractions containing these impurities was measured with a yeast two-hybrid assay incorporating the human (hER alpha) and a competitive binding assay for hER alpha (ELISA). In the yeast two-hybrid assay, estrogenic antagonist activity was found in two fractions, while estrogenic agonist activity was not found in any. In the ELISA method, the binding affinity to hER alpha was found in three fractions. It is probable that a comprehensive assessment of the estrogenic properties of commercial BADGE, and their implications for human health, will require examination of all its components as described here.

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Jun 15, 2005·Environmental Science & Technology·Masanori TerasakiMasakazu Makino

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Citations

Jul 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yan ChangJunfeng Jim Zhang
May 14, 2016·Environmental Toxicology and Chemistry·Ianina Hutler WolkowiczChristina Pérez Coll
Apr 4, 2017·Environmental Science & Technology·Jingchuan XueKurunthachalam Kannan

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