Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)

Fish & Shellfish Immunology
Zhitao QiTiehui Wang

Abstract

Atypical chemokine receptors (ACKRs) have emerged as key components of the chemokine system, with an essential regulatory function in innate and adaptive immune responses and inflammation. In mammals ACKR2 is a 'scavenging' receptor for inflammatory CC chemokines and plays a central role in the resolution of in vivo inflammatory responses. An ACKR2 like gene has been identified and cloned in rainbow trout (Teleostei) in the present study, enabling the further identification of this molecule in another group of ray-finned teleost fish (Holostei), in a lobe-finned fish (Sarcopterygii-coelacanth), and in reptiles. The identity of these ACKR2 molecules is supported by their conserved structure, and by phylogenetic tree and synteny analysis. Trout ACKR2 is highly expressed in spleen and head kidney, suggesting a homeostatic role of this receptor in limiting the availability of its potential ligands. Trout ACKR2 expression can be modulated in vivo by bacterial and parasitic infections, and in vitro by PAMPs (poly I:C and peptidoglycan) and cytokines (IL-6, TNF-α, IFN-γ and IL-21) in a time dependent manner. These patterns of expression and modulation suggest that trout ACKR2 is regulated in a complex way and has an important role in ...Continue Reading

References

Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jun 26, 2003·Nucleic Acids Research·Ramu ChennaJulie D Thompson
Jan 16, 2004·The Biochemical Journal·Paul E BlackburnGerard J Graham
Jul 6, 2004·Molecular Immunology·Kerry J Laing, Christopher J Secombes
Jun 1, 2005·Experimental Cell Research·Cristina LimatolaFabrizio Eusebi
Jul 6, 2005·Cytokine & Growth Factor Reviews·Massimo LocatiAlberto Mantovani
Aug 19, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Axel Meyer, Yves Van de Peer
Mar 25, 2008·FEBS Letters·Alex V KochetovAkinori Sarai
Nov 22, 2008·Molecular Immunology·Y LiuP Nie
Jun 23, 2009·Fish & Shellfish Immunology·P Díaz-RosalesC J Secombes
Dec 10, 2009·Nature Reviews. Genetics·Martin F Flajnik, Masanori Kasahara
Feb 27, 2010·Bioinformatics·Matthieu MuffatoHugues Roest Crollius
May 4, 2010·Cytokine & Growth Factor Reviews·Hisayuki NomiyamaOsamu Yoshie
Dec 15, 2010·Immunology and Cell Biology·Chris A H HansellRobert J B Nibbs
Feb 8, 2011·Developmental and Comparative Immunology·Hisayuki NomiyamaOsamu Yoshie
Mar 19, 2011·Developmental and Comparative Immunology·Alí Alejo, Carolina Tafalla
Jul 26, 2011·Developmental and Comparative Immunology·Jun Zou, Christopher J Secombes
Oct 8, 2011·Immunology·Laura D BennettNathalie Signoret
Nov 5, 2011·Nucleic Acids Research·Ivica LetunicPeer Bork
Apr 3, 2012·Immunologic Research·Sergio A Lira, Glaucia C Furtado
May 29, 2012·Immunity·Albert Zlotnik, Osamu Yoshie
Jun 16, 2012·Immunology Letters·G J GrahamM Thelen
Aug 15, 2012·Developmental and Comparative Immunology·Mansourah HusainTiehui Wang
Sep 4, 2012·Molecular Immunology·Cinzia CancellieriRaffaella Bonecchi
Nov 6, 2012·The Journal of Pathology·Gerard J Graham, Massimo Locati
Nov 14, 2012·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hisayuki NomiyamaOsamu Yoshie
May 25, 2013·Developmental and Comparative Immunology·Jun ChenJun Zou
May 31, 2013·European Journal of Immunology·Baubak Bajoghli
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Dec 10, 2013·Nature Reviews. Immunology·Robert J B Nibbs, Gerard J Graham
Jan 10, 2014·Nature·Byrappa VenkateshWesley C Warren
Mar 20, 2014·The Journal of Biological Chemistry·Kay D HewitGerard J Graham
Apr 1, 2014·Trends in Immunology·Annelien J M ZweemerAdriaan P IJzerman
Dec 3, 2014·Developmental and Comparative Immunology·Unni GrimholtBen F Koop
Jan 28, 2015·General and Comparative Endocrinology·Jun ZouChris J Secombes

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Nov 17, 2015·Biology·Steve Bird, Carolina Tafalla

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