Identification and function analysis of contrary genes in Dupuytren's contracture

Molecular Medicine Reports
Xianglu JiLijie Tian

Abstract

The present study aimed to analyze the expression of genes involved in Dupuytren's contracture (DC), using bioinformatic methods. The profile of GSE21221 was downloaded from the gene expression ominibus, which included six samples, derived from fibroblasts and six healthy control samples, derived from carpal-tunnel fibroblasts. A Distributed Intrusion Detection System was used in order to identify differentially expressed genes. The term contrary genes is proposed. Contrary genes were the genes that exhibited opposite expression patterns in the positive and negative groups, and likely exhibited opposite functions. These were identified using Coexpress software. Gene ontology (GO) function analysis was conducted for the contrary genes. A network of GO terms was constructed using the reduce and visualize gene ontology database. Significantly expressed genes (801) and contrary genes (98) were screened. A significant association was observed between Chitinase-3-like protein 1 and ten genes in the positive gene set. Positive regulation of transcription and the activation of nuclear factor-κB (NF-κB)-inducing kinase activity exhibited the highest degree values in the network of GO terms. In the present study, the expression of genes ...Continue Reading

References

May 1, 1993·Journal of Clinical Pathology·K S BairdS H Ralston
Jun 10, 2003·Plastic and Reconstructive Surgery·Ardeshir BayatWilliam E R Ollier
Jul 9, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Hiroaki Shimokawa, Akira Takeshita
Sep 20, 2005·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·A CordovaF Moschella
Sep 27, 2005·The Journal of Hand Surgery·Rachel M ReillyCharles A Goldfarb
Oct 20, 2005·The Journal of Biological Chemistry·Anneliese D ReckliesSuzanne M Bernier
Feb 14, 2006·The Journal of Hand Surgery·Lucy C LeeJames Chang
Mar 28, 2006·Biochemical Pharmacology·Bharat B Aggarwal, Shishir Shishodia
Jun 13, 2006·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·A L van Rijssen, P M N Werker
Sep 3, 2008·The Journal of Hand Surgery·Phillip JohnstonAdrian J Chojnowski
Sep 17, 2008·Current Protocols in Bioinformatics·Roderic D M Page
Nov 21, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mark D MurpheyMarkku Miettinen
Aug 3, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Neda MosakhaniSakari Knuutila
Dec 15, 2010·Bioinformatics·Michael E SmootTrey Ideker
Jul 27, 2011·PloS One·Fran SupekTomislav Šmuc
Dec 14, 2011·The New England Journal of Medicine·Lili WangCatherine J Wu
Nov 8, 2012·Nature Methods·Rintaro SaitoTrey Ideker

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.