Identification and Functional Analysis of Long Non-coding RNAs in Autism Spectrum Disorders

Frontiers in Genetics
Zhan TongJuan Wang

Abstract

Genetic and environmental factors, alone or in combination, contribute to the pathogenesis of autism spectrum disorder (ASD). Although many protein-coding genes have now been identified as disease risk genes for ASD, a detailed illustration of long non-coding RNAs (lncRNAs) associated with ASD remains elusive. In this study, we first identified ASD-related lncRNAs based on genomic variant data of individuals with ASD from a twin study. In total, 532 ASD-related lncRNAs were identified, and 86.7% of these ASD-related lncRNAs were further validated by an independent copy number variant (CNV) dataset. Then, the functions and associated biological pathways of ASD-related lncRNAs were explored by enrichment analysis of their three different types of functional neighbor genes (i.e., genomic neighbors, competing endogenous RNA (ceRNA) neighbors, and gene co-expression neighbors in the cortex). The results have shown that most of the functional neighbor genes of ASD-related lncRNAs were enriched in nervous system development, inflammatory responses, and transcriptional regulation. Moreover, we explored the differential functions of ASD-related lncRNAs in distinct brain regions by using gene co-expression network analysis based on tissu...Continue Reading

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Citations

Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sarva KeihaniEugenio F Fornasiero
Nov 9, 2021·Frontiers in Molecular Biosciences·Hani SabaieMaryam Rezazadeh

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Datasets Mentioned

BETA
GSE64018

Methods Mentioned

BETA
RNA-seq
ubiquitination

Software Mentioned

UCSC liftOver tool
BEDTools
WGCNA package
Ensembl
GeneMANIA
DrugPattern
DAVID
WGCNA
R

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