Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid

Journal of Bacteriology
C DeloménieJ-M Dupret

Abstract

Arylamine N-acetyltransferase activity has been described in various bacterial species. Bacterial N-acetyltransferases, including those from bacteria of the gut flora, may be involved in the metabolism of xenobiotics, thereby exerting physiopathological effects. We characterized these enzymes further by steady-state kinetics, time-dependent inhibition, and DNA hybridization in 40 species, mostly from the human intestinal microflora. We report for the first time N-acetyltransferase activity in 11 species of Proteobacteriaceae from seven genera: Citrobacter amalonaticus, Citrobacter farmeri, Citrobacter freundii, Klebsiella ozaenae, Klebsiella oxytoca, Klebsiella rhinoscleromatis, Morganella morganii, Serratia marcescens, Shigella flexneri, Plesiomonas shigelloides, and Vibrio cholerae. We estimated apparent kinetic parameters and found that 5-aminosalicylic acid, a compound efficient in the treatment of inflammatory bowel diseases, was acetylated with a catalytic efficiency 27 to 645 times higher than that for its isomer, 4-aminosalicylic acid. In contrast, para-aminobenzoic acid, a folate precursor in bacteria, was poorly acetylated. Of the wild-type strains studied, Pseudomonas aeruginosa was the best acetylator in terms of bo...Continue Reading

References

Jan 1, 1992·European Journal of Clinical Pharmacology·R A van HogezandJ H van Tongeren
Oct 1, 1991·Applied and Environmental Microbiology·H ItoN Kato
Aug 1, 1989·Gut·C NeutJ C Paris
May 1, 1983·Mutation Research·D M Maron, B N Ames
Nov 1, 1996·Trends in Microbiology·R D Berg
Nov 21, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B N Ames, L S Gold
Feb 4, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S E HsiehJ G Chung
Mar 10, 1998·Molecular Biology and Evolution·U Bergthorsson, H Ochman
Apr 29, 1998·Current Microbiology·F C Chang, J G Chung
Jun 3, 1998·Current Microbiology·S E HsiehJ G Chung
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J G Chung
Jun 22, 2000·Pharmacogenetics·D W HeinE Sim
Jul 6, 2000·Nature Structural Biology·J C SinclairM E Noble

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Citations

Feb 10, 2009·Inflammatory Bowel Diseases·Jaime KaufmanKevin P Rioux
Aug 16, 2008·European Journal of Clinical Pharmacology·Hendrik LückFritz Sörgel
Mar 12, 2003·Bioorganic & Medicinal Chemistry·Edward W BrookeRichard J Vickers
Mar 2, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Simon J HoltonEdith Sim
Dec 13, 2006·Journal of Bacteriology·Hirokazu SuzukiSueharu Horinouchi
Apr 23, 2002·Pharmacogenomics·Frédérique PompeoEdith Sim
Apr 7, 2010·Expert Opinion on Drug Metabolism & Toxicology·Ines A Pieper, Martin Bertau
Jun 27, 2009·Journal of Drug Targeting·Emma L McConnellAbdul W Basit
Jul 22, 2008·Drug Metabolism Reviews·Edith SimSotiria Boukouvala
Jan 8, 2013·Expert Opinion on Drug Metabolism & Toxicology·Xavier KubiakFernando Rodrigues-Lima
Nov 1, 2005·Drug Metabolism Reviews·Sotiria Boukouvala, Giannoulis Fakis
Aug 6, 2014·Journal of Pharmaceutical Sciences·Tiago SousaAbdul W Basit
Aug 7, 2008·International Journal of Pharmaceutics·Tiago SousaAbdul W Basit
Mar 15, 2016·Nature Reviews. Microbiology·Peter SpanogiannopoulosPeter J Turnbaugh
Jul 28, 2012·Toxicology·Dorothea DierolfBrunhilde Blömeke
Sep 4, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Ian D Wilson, Jeremy K Nicholson
Jun 24, 2017·Science·Nitzan KoppelEmily P Balskus
Jul 27, 2017·Journal of Medicinal Chemistry·Silvia TurroniMarco Candela
Jan 19, 2002·The Journal of Biological Chemistry·Adeel MushtaqEdith Sim
Oct 24, 2017·Immunological Investigations·Barbara E Ostrov, Daniel Amsterdam
May 22, 2018·British Journal of Pharmacology·Jacinta WalshNiall P Hyland
Aug 22, 2018·Journal of Toxicology and Environmental Health. Part a·Volker BornemannSusan S Schiffman
Sep 20, 2018·Drug Metabolism Reviews·Juanhong ZhangRong Wang
Jan 1, 2014·Applied and Environmental Microbiology·Shinji TakenakaKen-Ichi Yoshida
May 7, 2002·The Pharmacogenomics Journal·N J ButcherR F Minchin
May 17, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Lian Yee Yip, Eric Chun Yong Chan
Mar 3, 2020·Drug Metabolism Reviews·Yuan XieRong Wang
Mar 12, 2020·Nature Reviews. Rheumatology·Jose U ScherSteven B Abramson
Nov 2, 2019·World Journal of Microbiology & Biotechnology·Vasiliki GarefalakiSotiria Boukouvala

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