Identification and in silico analysis of cattle DExH/D box RNA helicases

SpringerPlus
Manish Kumar SutharSudhir Kumar Kashyap

Abstract

The helicases are motor proteins participating in a range of nucleic acid metabolisms. RNA helicase families are characterized by the presence of conserved motifs. This article reports a comprehensive in silico analysis of Bos taurus DExH/D helicase members. Bovine helicases were identified using the helicase domain sequences including 38 DDX (DEAD box) and 16 DHX (DEAH box) members. Signature motifs were used for the validation of these proteins. Putative sub cellular localization and phylogenetic relationship for these RNA helicases were established. Comparative analysis of these proteins with human DDX and DHX members was carried out. These bovine helicase have been assigned putative physiological functions. Present study of cattle DExH/D helicase will provides an invaluable source for the detailed biochemical and physiological research on these members.

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Citations

Aug 23, 2017·British Journal of Cancer·Shingo ItoSumiko Watanabe
Mar 14, 2017·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Changxu TianZhanjiang Liu

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Methods Mentioned

BETA
Bovine
Genome Sequencing
Human Genome Sequencing
environmental stress

Software Mentioned

MEGA
WoLF PSORT
Sequence Manipulating Suite
BLAST
BLASTP
FVxT
SAT
MEGA5
ClustalW
ClustalW2

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