PMID: 9643653Jun 27, 1998Paper

Identification and localization of type IV collagen chains in the inner ear cochlea

Connective Tissue Research
R KalluriBilly G Hudson

Abstract

Mutations in the genes encoding the alpha3(IV), alpha4(IV) and alpha5(IV) chains of type IV collagen have been implicated in the pathogenesis of Alport's syndrome, a hereditary disorder characterized by progressive nephropathy and sensorineural deafness. The known expression of these chains in kidney basement membranes supports the contention that they play a crucial role in the ultrafiltration function. Whether they play a role in auditory signal transduction remains unknown as heretofore, they have not been identified in the inner ear. In the present study, the expression of type IV collagen in cochlea of the inner ear of guinea pigs was determined. All six alpha-chains of type IV collagen were identified by biochemical and immunological methods. By indirect immunofluorescence, alpha1(IV) and alpha2(IV) chains were localized to the spiral limbus, basilar membrane and tectorial membrane. The alpha3(IV), alpha4(IV), alpha5(IV) and alpha6(IV) chains localized exclusively to the tectorial membrane and basilar membrane. These results suggest a possible role of type IV collagen chains in the active tuning of the basilar and tectorial membrane, an essential step in frequency discrimination and amplification of auditory signals.

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Citations

Jun 20, 2003·The New England Journal of Medicine·Billy G HudsonEric G Neilson
Nov 30, 2006·Scandinavian Journal of Urology and Nephrology·Thorir Svavar SigmundssonVidar Edvardsson
Oct 20, 2004·Human Pathology·Stephanie CaudroyPhilippe Birembaut
Jan 27, 2006·Auris, Nasus, Larynx·Michio MurakoshiHiroshi Wada
Oct 17, 2002·Journal of Neurobiology·Zheng-Yi Chen, David P Corey
Jun 29, 2017·Antioxidants & Redox Signaling·Selene ColonGautam Bhave
Aug 21, 2020·American Journal of Medical Genetics. Part a·Stefania BarozziUmberto Ambrosetti
May 29, 2002·Eye·M CahillP Eustace

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