Identification and location of albumin-like antigens in third-stage larva of W. bancrofti, in adult forms of Litomosoides chagasfilhoi and in the free-living nematode Caenorhabditis elegans

Micron : the International Research and Review Journal for Microscopy
L F SilvaC A Peixoto

Abstract

Antigens resembling those of host proteins have been identified on the surface of several filarial parasites, such as immunoglobulins and serum albumins. The origin of albumin-like antigens on filarial parasites remains unclear. Several authors suggested that they have been adsorbed, or that they were metabolic waste products from nutritional utilization of human albumin, or perhaps a contamination with human products. This study searched for human albumin-like antigens by Western blot and ultrastructural analyses on filarial parasites, third stage of W. bancrofti and adult females of Litomosoides chagasfilhoi, and on the free-living Caenorhabditis elegans nematode. Our results showed approximately 67kDa proteins recognized by anti-human albumin antibodies on extracts and excretory-secretory (ES) products of the third-stage W. bancrofti. Similar albumin-like proteins were also detected on the filarial parasite L. chagasfilhoi and on C. elegans extracts. The immunocytochemistry analysis showed human albumin-like antigens on similar tissues of these nematodes. These results provide evidence that these proteins have antigenic similarity and similar distribution in nematodes tissues. Our observations suggest that albumin-like antig...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Feb 1, 1992·Acta Tropica·G BardehleS Stirm
Jun 1, 1986·Annals of Tropical Medicine and Parasitology·V Zaman, E Narayanan
Feb 1, 1984·Molecular and Biochemical Parasitology·K P ForsythG F Mitchell
Dec 16, 1998·Science·UNKNOWN C. elegans Sequencing Consortium
Mar 2, 1999·Archives of Pathology & Laboratory Medicine·C A PeixotoG Dreyer
Aug 28, 1999·Acta Tropica·P BlochP E Simonsen
Feb 12, 2000·Biochimica Et Biophysica Acta·M W Kennedy
Jun 19, 2001·International Journal for Parasitology·R M MaizelsX Zang
Nov 15, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·C A PeixotoA Rocha
Jul 10, 2003·Parasite : Journal De La Société Française De Parasitologie·M Rodríguez-OsorioJ Gil
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roshanak Tolouei SemnaniThomas B Nutman
Dec 8, 2004·Micron : the International Research and Review Journal for Microscopy·L C AlvesC A Peixoto

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Citations

Jul 6, 2010·Experimental Parasitology·G A El-ShahawiM Bahgat
Jul 8, 2009·Micron : the International Research and Review Journal for Microscopy·G FilippidisN Tavernarakis
Jun 11, 2002·Biochemical and Biophysical Research Communications·Carla Beeber, Fred J Kieras

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