Identification and mode of inheritance of quantitative trait loci for secondary metabolite abundance in tomato

The Plant Cell
Saleh AlseekhAlisdair Robert Fernie

Abstract

A large-scale metabolic quantitative trait loci (mQTL) analysis was performed on the well-characterized Solanum pennellii introgression lines to investigate the genomic regions associated with secondary metabolism in tomato fruit pericarp. In total, 679 mQTLs were detected across the 76 introgression lines. Heritability analyses revealed that mQTLs of secondary metabolism were less affected by environment than mQTLs of primary metabolism. Network analysis allowed us to assess the interconnectivity of primary and secondary metabolism as well as to compare and contrast their respective associations with morphological traits. Additionally, we applied a recently established real-time quantitative PCR platform to gain insight into transcriptional control mechanisms of a subset of the mQTLs, including those for hydroxycinnamates, acyl-sugar, naringenin chalcone, and a range of glycoalkaloids. Intriguingly, many of these compounds displayed a dominant-negative mode of inheritance, which is contrary to the conventional wisdom that secondary metabolite contents decreased on domestication. We additionally performed an exemplary evaluation of two candidate genes for glycolalkaloid mQTLs via the use of virus-induced gene silencing. The com...Continue Reading

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Citations

Nov 15, 2015·Plant Science : an International Journal of Experimental Plant Biology·Federico ScossaAlisdair R Fernie
Nov 15, 2015·Plant Science : an International Journal of Experimental Plant Biology·Maria UrrutiaAmparo Monfort
Apr 20, 2016·Frontiers in Plant Science·Roberta CalafioreAmalia Barone
Jan 7, 2016·Annual Review of Plant Biology·Gad GaliliAlisdair R Fernie
Jun 1, 2016·Frontiers in Plant Science·Svetlana BaldinaAndrea Mazzucato
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May 8, 2018·The Plant Journal : for Cell and Molecular Biology·Saleh Alseekh, Alisdair R Fernie
Sep 20, 2017·Journal of Experimental Botany·Takayuki TohgeAlisdair R Fernie
Sep 20, 2018·The Plant Journal : for Cell and Molecular Biology·Chuanying Fang, Jie Luo
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