Identification and partial purification of an antigen (omega 1) from Schistosoma mansoni eggs which is putatively hepatotoxic in T-cell deprived mice

Transactions of the Royal Society of Tropical Medicine and Hygiene
D W DunneM J Doenhoff

Abstract

T-cell deprived mice heavily infected with Schistosoma mansoni suffer from severe microvesicular damage to hepatocytes within seven weeks of infection. The damage can be prevented by administration of serum (CIS) obtained from mice chronically infected with S. mansoni or from mice immunized with intact or homogenized S. mansoni eggs. Reaction of serum samples from individual chronically infected mice in immunoelectrophoresis with S. mansoni egg homogenate has enabled the identification of at least 12 distinct immuno precipitation reactions. Precipitating antibody against one S. mansoni egg antigen, omega 1, has been detected in all mice with patent chronic infections, and anti-omega 1 antibody is the most concentrated of the precipitating anti-egg antibody species in pooled CIS. Pooled serum obtained from infected intact mice reacting predominantly against omega 1 was found partially to prevent the hepatotoxicity reaction on transfer to infected deprived mice. Serum samples from mice injected with egg homogenate fractionated either by preparative electrophoresis or by cation exchange chromatography, and containing antibodies reactive with antigen omega 1 in immunoprecipitation, were fully protective against liver cell damage in...Continue Reading

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Citations

Jan 1, 1981·Journal of Immunological Methods·A Voller, D De Savigny
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W DunneM J Doenhoff
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E ButterworthR F Sturrock
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E ButterworthJ H Ouma
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffS Lucas
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·E R JamesJ G Else
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffJ Bain
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffJ E Lillywhite
Nov 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J SimpsonF Rumjanek
Jan 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffJ Bain
Jun 1, 1987·Diagnostic Microbiology and Infectious Disease·S E Maddison
Aug 23, 2000·Immunology Today·A W CheeverT A Wynn
Oct 17, 2006·Parasitology Today·M J Doenhoff
May 1, 1984·The Journal of Experimental Medicine·D A HarnJ R David
May 1, 1993·Parasite Immunology·A M AgnewM J Doenhoff
Feb 26, 2010·Journal of Clinical Microbiology·Dean B EverettRichard J Hayes
Oct 29, 2004·Journal of Clinical Pathology·P TurnerP L Chiodini
Sep 25, 2010·Annals of Tropical Medicine and Parasitology·J BlighM J Doenhoff
Nov 1, 2011·PLoS Neglected Tropical Diseases·Maha-Hamadien AbdullaConor R Caffrey
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Jul 1, 1989·Parasite Immunology·A M AgnewM J Doenhoff
Jul 14, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·C M VendrameP P Chieffi
Jun 29, 2011·European Journal of Immunology·Paola ZacconeAnne Cooke

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