Identification and pharmacokinetics of multiple potential bioactive constituents after oral administration of radix astragali on cyclophosphamide-induced immunosuppression in Balb/c mice

International Journal of Molecular Sciences
Menghua LiuJingyu He

Abstract

Radix Astragali (RA) is one of the commonly-used traditional Chinese medicines (TCMs) with an immunomodulatory effect confirmed in the clinic. In order to better understand the material basis for the therapeutic effects, this study was to investigate the absorbed components and their pharmacokinetic profile after oral administration of RA on cyclophosphamide-induced immunosuppression in Balb/c mice. As a result, 51 compounds in RA extract and 31 prototype compounds with nine metabolites were detected in mice plasma by the ultra-fast liquid chromatography (UFLC)-DAD-Q-TOF-MS/MS method. The pharmacokinetic parameters of five main constituents, including calycosin-7-O-glucoside, ononin, calycosin, formononetin and astragaloside IV, were obtained using HPLC-MS/MS. These results offered useful information for research on the pharmacological mechanism of RA and for its further development.

References

Feb 1, 1982·Environmental Health Perspectives·L Rasmussen, A Arvin
Sep 12, 2006·Journal of Ethnopharmacology·Guan-Cheng HuangChing-Chiung Wang
Jun 24, 2008·Immunopharmacology and Immunotoxicology·Q Y LiS Q Liu
Jun 18, 2009·World Journal of Gastroenterology : WJG·Rui-Ping ZhangDi-Jiong Wu
Sep 22, 2010·Molecular Aspects of Medicine·Alan CrozierMichael N Clifford
Mar 2, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Chunhua ZhuAihua Zhang
Nov 6, 2012·Journal of Ethnopharmacology·Chao GuoAidong Wen
Feb 5, 2013·Pharmaceutical Biology·Xiao-Yan HeChun-Jie Wu
Apr 24, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J TianJ Chen
Jun 19, 2013·Chemistry & Biodiversity·Li-Peng YangJian-Qin Jiang
Aug 7, 2013·International Journal of Biological Macromolecules·Xiaofei WangJunhu Yao
Feb 26, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiaofan WangXiaohui Chen
May 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiao-Hua LiuShi-Lan Feng

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Citations

Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meng-Hua LiuJing-Yu He
Jul 5, 2017·Clinical Pharmacology and Therapeutics·Guoxiang XieWei Jia
Sep 30, 2017·The Journal of Pharmacy and Pharmacology·Mario MarescaLorenzo Di Cesare Mannelli
Jan 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan LiJin-Ao Duan
Jan 29, 2020·Andrologia·Sunny O AbarikwuShio Kumar Singh
Dec 7, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sha DiXiaolin Tong
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emmanuel Cabañas-GarcíaEugenio Pérez-Molphe Balch
May 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Guowei GongZhen Wen

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Methods Mentioned

BETA
NMR

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