PMID: 11934492Apr 6, 2002Paper

Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis

FEMS Microbiology Letters
Stephen J BillingtonB Helen Jost

Abstract

Four genes, fagA, B, C and D, encoding products with 32-47% identity to proteins involved in bacterial iron uptake systems, were identified immediately downstream of the Corynebacterium pseudotuberculosis phospholipase D gene. beta-Galactosidase assays on a C. pseudotuberculosis strain carrying a fagA-lacZ fusion indicated that the putative fagABC operon was poorly expressed in iron-rich media. However, similar experiments in iron-limited media resulted in an approximately three-fold increase in beta-galactosidase activity, suggesting that this operon is regulated by iron in vitro. Although no defect in iron utilization could be determined for a C. pseudotuberculosis fagB(C) mutant in vitro, this mutant showed reduced virulence compared to wild-type in a goat model of caseous lymphadenitis. Thus, expression of the fag genes in the host appears to contribute to virulence.

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Citations

Feb 7, 2009·Expert Review of Vaccines·Fernanda A DorellaVasco Azevedo
Jan 1, 2013·Computational and Structural Biotechnology Journal·Fernanda A DorellaArtur Silva
Sep 25, 2017·BMC Microbiology·Cleber Eduardo GalvãoGrácia Maria Soares Rosinha
Jul 26, 2013·Genetics and Molecular Biology·Maria da Conceição Aquino de SáMateus Matiuzzi da Costa
Sep 18, 2015·Open Forum Infectious Diseases·Lars HeggelundStig Sophus Frøland
May 22, 2018·Bioinformatics and Biology Insights·Daniela Droppa-AlmeidaFrancine Ferreira Padilha
Jun 7, 2019·International Journal of Molecular Sciences·Magdalena RzewuskaMałgorzata Gieryńska
Aug 21, 2019·BMC Genomics·Izabela Coimbra IbraimVasco Azevedo
Jan 26, 2021·Frontiers in Cellular and Infection Microbiology·Qiqi PanQixiao Zhai
Mar 7, 2021·Microorganisms·Doglas PariseJan Baumbach
May 23, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Fouzia NasimInsaf Ahmed Qureshi
Jul 6, 2021·Frontiers in Microbiology·Mariana Teixeira Dornelles PariseJan Baumbach

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